NET5_RAT
ID NET5_RAT Reviewed; 456 AA.
AC D3ZT86;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Netrin-5;
DE AltName: Full=Netrin-1-like protein;
DE Flags: Precursor;
GN Name=Ntn5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=25941474; DOI=10.3389/fncel.2015.00146;
RA Yamagishi S., Yamada K., Sawada M., Nakano S., Mori N., Sawamoto K.,
RA Sato K.;
RT "Netrin-5 is highly expressed in neurogenic regions of the adult brain.";
RL Front. Cell. Neurosci. 9:146-146(2015).
CC -!- FUNCTION: Plays a role in neurogenesis. Prevents motor neuron cell body
CC migration out of the neural tube. {ECO:0000250|UniProtKB:Q3UQ22}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the olfactory bulb, the cerebral
CC cortex, the hippocampus, and the cerebellum in the adult brain (at
CC protein level) (PubMed:25941474). Strongly expressed in the
CC subventricular zone,rostral migrate stream, and the subgranular zone of
CC the dentate gyrus in the hippocampus (PubMed:25941474).
CC {ECO:0000269|PubMed:25941474}.
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DR EMBL; AABR07071908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001166997.1; NM_001173526.1.
DR RefSeq; XP_017444634.1; XM_017589145.1.
DR AlphaFoldDB; D3ZT86; -.
DR SMR; D3ZT86; -.
DR STRING; 10116.ENSRNOP00000028524; -.
DR GlyGen; D3ZT86; 2 sites.
DR PaxDb; D3ZT86; -.
DR Ensembl; ENSRNOT00000028524; ENSRNOP00000028524; ENSRNOG00000021016.
DR GeneID; 308587; -.
DR KEGG; rno:308587; -.
DR UCSC; RGD:1565197; rat.
DR CTD; 126147; -.
DR RGD; 1565197; Ntn5.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00940000161874; -.
DR HOGENOM; CLU_018213_0_0_1; -.
DR InParanoid; D3ZT86; -.
DR OMA; SCPQACA; -.
DR OrthoDB; 858946at2759; -.
DR TreeFam; TF352481; -.
DR PRO; PR:D3ZT86; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000021016; Expressed in skeletal muscle tissue and 8 other tissues.
DR GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR GO; GO:0008045; P:motor neuron axon guidance; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 2.
DR SUPFAM; SSF50242; SSF50242; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50189; NTR; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Disulfide bond; Glycoprotein;
KW Laminin EGF-like domain; Neurogenesis; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..456
FT /note="Netrin-5"
FT /evidence="ECO:0000255"
FT /id="PRO_5003052988"
FT DOMAIN 173..227
FT /note="Laminin EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DOMAIN 228..277
FT /note="Laminin EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DOMAIN 298..442
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 173..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 175..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 193..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 205..225
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 228..240
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 230..247
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 249..258
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 261..275
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT DISULFID 298..384
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 302..386
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 317..442
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
SQ SEQUENCE 456 AA; 49030 MW; D3B0E08613FB7CBF CRC64;
MADYRTLFSP SGTGSAVTVL VALSLLLLLS QATSDPCYDP GGRPRFCLPP VTQLVGKAAA
PCSQTCALPA DSPDPVCNGT LTLDLDGSFL LTSVTLRFCT AGPPALVLSA AWAIGGPWRP
LWRRPAWPGV LGGPKKVTFH SPPGPKTRIV ASYLRVELGG KAGLVTTGVR GRCQCHGHAA
RCAARAQPPR CRCRHHTTGP GCESCRPSHR DWPWRPATPQ HPHPCLPCQC HPIGATGGMC
NQTSGQCSCK LGVTGLTCNH CGPGYQQSRS PRMPCQRIPE ATTALATTPV ASRSDPQCQG
YCNVSVSSVH MNLQKYCQQD YVLHARVAES AQVSASSSLS SLSEAVGPEW WRLAVHVLAV
FKQRAWPVRR GSQEAWVPRA DLSCGCLRLR PGADYLLLGR AAENHTDPAH LILNRHSLAL
PWRPRWAGPL RRLQQKERGG ACRGLLPPTR SPGPRN
