ID   NEU1_ANSAN              Reviewed;          93 AA.
AC   P35519;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Neurophysin 1;
DE   AltName: Full=VLDV-neurophysin;
OS   Anser anser anser (Western greylag goose).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8844;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pituitary;
RX   PubMed=2276874; DOI=10.1111/j.1399-3011.1990.tb01306.x;
RA   Michel G., Levy B., Chauvet M.-T., Chauvet J., Acher R.;
RT   "Complete amino acid sequence of goose VLDV-neurophysin. Traces of a
RT   putative gene conversion between promesotocin and provasotocin genes.";
RL   Int. J. Pept. Protein Res. 36:457-464(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 9-17 AND 20-43.
RX   PubMed=3427215; DOI=10.1007/bf01127675;
RA   Levy B., Michel G., Chauvet J., Chauvet M.-T., Acher R.;
RT   "Gene conversion in avian mesotocin and vasotocin genes: a recurrent
RT   mechanism linking two neurohypophysial precursor lineages?";
RL   Biosci. Rep. 7:631-636(1987).
CC   -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; A60357; A60357.
DR   AlphaFoldDB; P35519; -.
DR   SMR; P35519; -.
DR   PRIDE; P35519; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..93
FT                   /note="Neurophysin 1"
FT                   /id="PRO_0000160934"
FT   DISULFID        10..54
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        13..27
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        21..44
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        28..34
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        61..74
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        68..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        75..80
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   93 AA;  9676 MW;  25C954C9CCBC0F23 CRC64;
     AVLDGDVRKC LPCGPRNRGR CFGPRICCGE ELGCYLGTPE TLRCQEESFL PTPCESGRKP
     CGGDGASCAA PGICCSSEGC VADPACEREA LFA