NEU1_BALPH
ID NEU1_BALPH Reviewed; 9 AA.
AC P69056; P01188; P32878;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 11-DEC-2019, entry version 33.
DE RecName: Full=Oxytocin;
DE AltName: Full=Ocytocin;
GN Name=OXT;
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770;
RN [1]
RP PROTEIN SEQUENCE, DISULFIDE BOND, AND AMIDATION AT GLY-9.
RX PubMed=14118277; DOI=10.1038/201191a0;
RA Acher R., Chauvet J., Chauvet M.-T.;
RT "Isolation of finback whale oxytocin and vasopressin.";
RL Nature 201:191-192(1964).
CC -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; A93147; A93147.
DR SMR; P69056; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR Pfam; PF00220; Hormone_4; 1.
DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT PEPTIDE 1..9
FT /note="Oxytocin"
FT /id="PRO_0000044082"
FT MOD_RES 9
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:14118277"
FT DISULFID 1..6
FT /evidence="ECO:0000269|PubMed:14118277"
SQ SEQUENCE 9 AA; 1010 MW; 17F8376EB456D04B CRC64;
CYIQNCPLG