ID   NEU1_CATCO              Reviewed;         154 AA.
AC   P15210;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Isotocin-neurophysin IT 1;
DE   Contains:
DE     RecName: Full=Isotocin;
DE              Short=IT;
DE   Contains:
DE     RecName: Full=Neurophysin IT 1;
DE   Flags: Precursor;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2583084; DOI=10.1002/j.1460-2075.1989.tb08435.x;
RA   Figueroa J., Morley S.D., Heierhorst J., Krentler C., Lederis K.,
RA   Richter D.;
RT   "Two isotocin genes are present in the white sucker Catostomus commersoni
RT   both lacking introns in their protein coding regions.";
RL   EMBO J. 8:2873-2877(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2748582; DOI=10.1073/pnas.86.14.5242;
RA   Heierhorst J., Morley S.D., Figueroa J., Krentler C., Lederis K.,
RA   Richter D.;
RT   "Vasotocin and isotocin precursors from the white sucker, Catostomus
RT   commersoni: cloning and sequence analysis of the cDNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5242-5246(1989).
CC   -!- FUNCTION: Isotocin causes contraction of smooth muscles.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; X16621; CAA34618.1; -; mRNA.
DR   PIR; S06018; A33896.
DR   AlphaFoldDB; P15210; -.
DR   SMR; P15210; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Signal.
FT   SIGNAL          1..20
FT   PEPTIDE         21..29
FT                   /note="Isotocin"
FT                   /id="PRO_0000020544"
FT   CHAIN           32..154
FT                   /note="Neurophysin IT 1"
FT                   /id="PRO_0000020545"
FT   MOD_RES         29
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..26
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        42..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        45..59
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..76
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        60..66
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        93..105
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        99..117
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        106..111
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   154 AA;  16053 MW;  16FCB11A9DFFC517 CRC64;
     MSGSMFSVFS LLYLLSVCSA CYISNCPIGG KRAIQDSPSR QCMSCGPGDR GRCFGPSICC
     GEGLGCLLGS PETQRCLEED FLPSPCEAGG KVCGYEGRCA APGVCCDSEG CSVDQSCVDG
     DGDATAVSQP ASSQDLLLKL LHLSNPAHPY RLHQ