NEU1_HIPAM
ID NEU1_HIPAM Reviewed; 9 AA.
AC P69044; P01188; P32878;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 11-DEC-2019, entry version 34.
DE RecName: Full=Oxytocin;
DE AltName: Full=Ocytocin;
GN Name=OXT;
OS Hippopotamus amphibius (Hippopotamus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Ancodonta;
OC Hippopotamidae; Hippopotamus.
OX NCBI_TaxID=9833;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=5406007; DOI=10.1016/0016-6480(69)90265-2;
RA Ferguson D.R., Pickering B.T.;
RT "Arginine and lysine vasopressins in the hippopotamus neurohypophysis.";
RL Gen. Comp. Endocrinol. 13:425-429(1969).
CC -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR PIR; A91466; A91466.
DR SMR; P69044; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR Pfam; PF00220; Hormone_4; 1.
DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT PEPTIDE 1..9
FT /note="Oxytocin"
FT /id="PRO_0000044083"
FT MOD_RES 9
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT DISULFID 1..6
FT /evidence="ECO:0000250|UniProtKB:P01175"
SQ SEQUENCE 9 AA; 1010 MW; 17F8376EB456D04B CRC64;
CYIQNCPLG