NEU1_MOUSE
ID NEU1_MOUSE Reviewed; 125 AA.
AC P35454;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Oxytocin-neurophysin 1;
DE Short=OT-NPI;
DE Contains:
DE RecName: Full=Oxytocin;
DE AltName: Full=Ocytocin;
DE Contains:
DE RecName: Full=Neurophysin 1;
DE Flags: Precursor;
GN Name=Oxt;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2176709; DOI=10.1016/0169-328x(90)90045-f;
RA Hara Y., Battey J., Gainer H.;
RT "Structure of mouse vasopressin and oxytocin genes.";
RL Brain Res. Mol. Brain Res. 8:319-324(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ILS, and ISS;
RX PubMed=11471062; DOI=10.1007/s00335-001-1001-x;
RA Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J.,
RA Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.;
RT "High-throughput sequence identification of gene coding variants within
RT alcohol-related QTLs.";
RL Mamm. Genome 12:657-663(2001).
CC -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC {ECO:0000250|UniProtKB:P01178}.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR EMBL; M88355; AAC42024.1; -; Genomic_DNA.
DR EMBL; AF483508; AAL90782.1; -; mRNA.
DR EMBL; AF483509; AAL90783.1; -; mRNA.
DR CCDS; CCDS16745.1; -.
DR PIR; A43755; A43755.
DR RefSeq; NP_035155.1; NM_011025.4.
DR AlphaFoldDB; P35454; -.
DR SMR; P35454; -.
DR BioGRID; 201996; 3.
DR STRING; 10090.ENSMUSP00000028764; -.
DR PaxDb; P35454; -.
DR PeptideAtlas; P35454; -.
DR PRIDE; P35454; -.
DR ProteomicsDB; 252815; -.
DR Antibodypedia; 7257; 260 antibodies from 36 providers.
DR Ensembl; ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301.
DR GeneID; 18429; -.
DR KEGG; mmu:18429; -.
DR UCSC; uc008mjg.2; mouse.
DR CTD; 5020; -.
DR MGI; MGI:97453; Oxt.
DR VEuPathDB; HostDB:ENSMUSG00000027301; -.
DR eggNOG; ENOG502S2CT; Eukaryota.
DR GeneTree; ENSGT00390000004511; -.
DR HOGENOM; CLU_125770_1_0_1; -.
DR InParanoid; P35454; -.
DR OMA; YIQNCPP; -.
DR OrthoDB; 1548839at2759; -.
DR PhylomeDB; P35454; -.
DR TreeFam; TF333018; -.
DR Reactome; R-MMU-388479; Vasopressin-like receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 18429; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Oxt; mouse.
DR PRO; PR:P35454; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P35454; protein.
DR Bgee; ENSMUSG00000027301; Expressed in paraventricular nucleus of hypothalamus and 38 other tissues.
DR ExpressionAtlas; P35454; baseline and differential.
DR Genevisible; P35454; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0043195; C:terminal bouton; ISO:MGI.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISO:MGI.
DR GO; GO:0031855; F:oxytocin receptor binding; ISO:MGI.
DR GO; GO:0042756; P:drinking behavior; ISO:MGI.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR GO; GO:0007625; P:grooming behavior; ISO:MGI.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0042538; P:hyperosmotic salinity response; IEA:Ensembl.
DR GO; GO:0060179; P:male mating behavior; IEA:Ensembl.
DR GO; GO:0002125; P:maternal aggressive behavior; IEA:Ensembl.
DR GO; GO:0042711; P:maternal behavior; ISO:MGI.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; ISO:MGI.
DR GO; GO:0035811; P:negative regulation of urine volume; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0045925; P:positive regulation of female receptivity; ISO:MGI.
DR GO; GO:0060450; P:positive regulation of hindgut contraction; ISO:MGI.
DR GO; GO:0010701; P:positive regulation of norepinephrine secretion; ISO:MGI.
DR GO; GO:0045778; P:positive regulation of ossification; ISO:MGI.
DR GO; GO:0060406; P:positive regulation of penile erection; ISO:MGI.
DR GO; GO:0032308; P:positive regulation of prostaglandin secretion; ISO:MGI.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; ISO:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:MGI.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; ISO:MGI.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; ISO:MGI.
DR GO; GO:0044058; P:regulation of digestive system process; ISO:MGI.
DR GO; GO:0002027; P:regulation of heart rate; ISO:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR GO; GO:0045472; P:response to ether; IEA:Ensembl.
DR GO; GO:0043207; P:response to external biotic stimulus; ISS:AgBase.
DR GO; GO:0032094; P:response to food; ISS:AgBase.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; ISS:AgBase.
DR GO; GO:0014070; P:response to organic cyclic compound; ISO:MGI.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; ISO:MGI.
DR GO; GO:0034695; P:response to prostaglandin E; IEA:Ensembl.
DR GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR GO; GO:0009744; P:response to sucrose; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; ISO:MGI.
DR GO; GO:0035176; P:social behavior; ISO:MGI.
DR GO; GO:0042713; P:sperm ejaculation; ISO:MGI.
DR Gene3D; 2.60.9.10; -; 1.
DR InterPro; IPR000981; Neurhyp_horm.
DR InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR PANTHER; PTHR11681; PTHR11681; 1.
DR Pfam; PF00220; Hormone_4; 1.
DR Pfam; PF00184; Hormone_5; 1.
DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR PRINTS; PR00831; NEUROPHYSIN.
DR SMART; SM00003; NH; 1.
DR SUPFAM; SSF49606; SSF49606; 1.
DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT PEPTIDE 20..28
FT /note="Oxytocin"
FT /id="PRO_0000020497"
FT CHAIN 32..125
FT /note="Neurophysin 1"
FT /id="PRO_0000020498"
FT MOD_RES 28
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT DISULFID 20..25
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 41..85
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 44..58
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 52..75
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 59..65
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 92..104
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 98..116
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 105..110
FT /evidence="ECO:0000250|UniProtKB:P01175"
SQ SEQUENCE 125 AA; 12851 MW; 96D3135EBBA2436E CRC64;
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES
AFSER
