ID   NEU1_ONCMA              Reviewed;         157 AA.
AC   Q07663;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Isotocin-neurophysin IT 1;
DE   Contains:
DE     RecName: Full=Isotocin;
DE              Short=IT;
DE   Contains:
DE     RecName: Full=Neurophysin IT 1;
DE   Flags: Precursor;
OS   Oncorhynchus masou (Cherry salmon) (Masu salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=1369229;
RA   Suzuki M., Hyodo S., Urano A.;
RT   "Cloning and sequence analyses of vasotocin and isotocin precursor cDNAs in
RT   the masu salmon, Oncorhynchus masou: evolution of neurohypophysial hormone
RT   precursors.";
RL   Zool. Sci. 9:157-167(1992).
CC   -!- FUNCTION: Isotocin causes contraction of smooth muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC60744.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA01738.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D10944; BAA01738.1; ALT_INIT; mRNA.
DR   EMBL; S58721; AAC60744.2; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q07663; -.
DR   SMR; Q07663; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         21..29
FT                   /note="Isotocin"
FT                   /id="PRO_0000020560"
FT   CHAIN           33..157
FT                   /note="Neurophysin IT 1"
FT                   /id="PRO_0000020561"
FT   MOD_RES         29
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..26
FT   DISULFID        42..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        45..59
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..76
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        60..66
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        93..106
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        100..118
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        107..112
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   157 AA;  16497 MW;  73E177614CF5F865 CRC64;
     MFGTSVSALC LLFLLSVCTA CYISNCPIGG KRSALAFPSR KCMSCGPGDR GRCFGPNICC
     GEGMGCYVGS PEAAGCVEEN YLPSPCEVGG RVCGSEEGRC AAPGICCDVE GCSIDQSCTE
     EDEAEYISQS VSSSHGHDLL MKLLNMISHT PPHRVHK