ID   NEU1_PAPHA              Reviewed;          85 AA.
AC   P32005;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Oxytocin-neurophysin 1;
DE            Short=OT-NPI;
DE   Contains:
DE     RecName: Full=Oxytocin;
DE     AltName: Full=Ocytocin;
DE   Contains:
DE     RecName: Full=Neurophysin 1;
DE   Flags: Precursor; Fragment;
GN   Name=OXT;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2249637; DOI=10.1210/endo-127-6-2990;
RA   Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.;
RT   "Expression of the oxytocin and vasopressin genes in human and baboon
RT   gonadal tissues.";
RL   Endocrinology 127:2990-2996(1990).
CC   -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC       (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC   -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC       Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC       nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC       {ECO:0000250|UniProtKB:P01178}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M62612; AAA16517.1; -; mRNA.
DR   AlphaFoldDB; P32005; -.
DR   SMR; P32005; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone.
FT   PEPTIDE         <1..3
FT                   /note="Oxytocin"
FT                   /id="PRO_0000020499"
FT   CHAIN           7..>85
FT                   /note="Neurophysin 1"
FT                   /id="PRO_0000020500"
FT   MOD_RES         3
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..60
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        19..33
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        27..50
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        34..40
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        67..79
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        80..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   NON_TER         1
FT   NON_TER         85
SQ   SEQUENCE   85 AA;  8643 MW;  E4C4DA826205CCC0 CRC64;
     PLGGKRAAPD LDVRKCLPCG PGGKGRCFGP NICCAEELGC FVGTAEALRC QEENYLPSPC
     QSGQKACGSG GRCAVFGLCC SPDGC