NEU1_PIG
ID NEU1_PIG Reviewed; 125 AA.
AC P01177;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Oxytocin-neurophysin 1;
DE Short=OT-NPI;
DE Contains:
DE RecName: Full=Oxytocin;
DE AltName: Full=Ocytocin;
DE Contains:
DE RecName: Full=Neurophysin 1;
DE Flags: Precursor;
GN Name=OXT;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1971513; DOI=10.1677/jme.0.0040151;
RA Rehbein M., Richter D.;
RT "Poly(A) tail length of oxytocin- and lysine vasopressin-encoding mRNAs
RT increases during development in the porcine hypothalamus.";
RL J. Mol. Endocrinol. 4:151-158(1990).
RN [2]
RP PROTEIN SEQUENCE OF 20-28, AND AMIDATION AT GLY-28.
RX PubMed=13022701; DOI=10.1016/s0021-9258(18)38532-6;
RA Pierce J.G., Gordon S., du Vigneaud V.;
RT "Further distribution studies on the oxytocic hormone of the posterior lobe
RT of the pituitary gland and the preparation of an active crystalline
RT flavianate.";
RL J. Biol. Chem. 199:929-940(1952).
RN [3]
RP PROTEIN SEQUENCE OF 32-124.
RX PubMed=428540; DOI=10.1016/0014-5793(79)80146-5;
RA Chauvet M.-T., Codogno P., Chauvet J., Acher R.;
RT "Comparison between MSEL- and VLDV-neurophysins. Complete amino acid
RT sequences of porcine and bovine VLDV-neurophysins.";
RL FEBS Lett. 98:37-40(1979).
CC -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC {ECO:0000250|UniProtKB:P01178}.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR PIR; B60970; NFPG1.
DR RefSeq; NP_001161061.1; NM_001167589.1.
DR AlphaFoldDB; P01177; -.
DR SMR; P01177; -.
DR STRING; 9823.ENSSSCP00000007626; -.
DR PaxDb; P01177; -.
DR Ensembl; ENSSSCT00000007837; ENSSSCP00000007626; ENSSSCG00000007164.
DR Ensembl; ENSSSCT00015081984; ENSSSCP00015033170; ENSSSCG00015061398.
DR Ensembl; ENSSSCT00025060419; ENSSSCP00025025625; ENSSSCG00025044498.
DR Ensembl; ENSSSCT00035057212; ENSSSCP00035022995; ENSSSCG00035043065.
DR Ensembl; ENSSSCT00045003680; ENSSSCP00045002331; ENSSSCG00045002354.
DR Ensembl; ENSSSCT00050079009; ENSSSCP00050033996; ENSSSCG00050057938.
DR Ensembl; ENSSSCT00060013656; ENSSSCP00060005234; ENSSSCG00060010502.
DR Ensembl; ENSSSCT00065088251; ENSSSCP00065038604; ENSSSCG00065064290.
DR Ensembl; ENSSSCT00070000302; ENSSSCP00070000249; ENSSSCG00070000178.
DR GeneID; 100152272; -.
DR KEGG; ssc:100152272; -.
DR CTD; 5020; -.
DR VGNC; VGNC:96466; OXT.
DR eggNOG; ENOG502S2CT; Eukaryota.
DR GeneTree; ENSGT00390000004511; -.
DR HOGENOM; CLU_125770_1_0_1; -.
DR InParanoid; P01177; -.
DR OMA; YIQNCPP; -.
DR OrthoDB; 1548839at2759; -.
DR TreeFam; TF333018; -.
DR Reactome; R-SSC-388479; Vasopressin-like receptors.
DR Reactome; R-SSC-416476; G alpha (q) signalling events.
DR Proteomes; UP000008227; Chromosome 17.
DR Proteomes; UP000314985; Chromosome 17.
DR Bgee; ENSSSCG00000007164; Expressed in hypothalamus and 9 other tissues.
DR Genevisible; P01177; SS.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0031855; F:oxytocin receptor binding; IBA:GO_Central.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0043207; P:response to external biotic stimulus; ISS:AgBase.
DR GO; GO:0032094; P:response to food; ISS:AgBase.
DR GO; GO:0009612; P:response to mechanical stimulus; ISS:AgBase.
DR Gene3D; 2.60.9.10; -; 1.
DR InterPro; IPR000981; Neurhyp_horm.
DR InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR PANTHER; PTHR11681; PTHR11681; 1.
DR Pfam; PF00220; Hormone_4; 1.
DR Pfam; PF00184; Hormone_5; 1.
DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR PRINTS; PR00831; NEUROPHYSIN.
DR SMART; SM00003; NH; 1.
DR SUPFAM; SSF49606; SSF49606; 1.
DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hormone; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:13022701"
FT PEPTIDE 20..28
FT /note="Oxytocin"
FT /id="PRO_0000020501"
FT CHAIN 32..125
FT /note="Neurophysin 1"
FT /id="PRO_0000020502"
FT MOD_RES 28
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:13022701"
FT DISULFID 20..25
FT DISULFID 41..85
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 44..58
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 52..75
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 59..65
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 92..104
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 98..116
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 105..110
FT /evidence="ECO:0000250|UniProtKB:P01175"
SQ SEQUENCE 125 AA; 12887 MW; AA20808066E25B5F CRC64;
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRK CLPCGPGGKG RCFGPSICCG
DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSEGRCAA AGICCNPDGC RFDPACDPEA
TFSQR
