ID   NEU1_RABIT              Reviewed;           9 AA.
AC   P69043; P01188; P32878;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 35.
DE   RecName: Full=Oxytocin;
DE   AltName: Full=Ocytocin;
GN   Name=OXT;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE, DISULFIDE BOND, AND AMIDATION AT GLY-9.
RX   PubMed=5150741; DOI=10.1016/s0300-9084(71)80199-2;
RA   Chauvet J., Chauvet M.-T., Acher R.;
RT   "Evolution of neurohypophyseal hormones: isolation of active principles
RT   from rabbits and rats.";
RL   Biochimie 53:1099-1104(1971).
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland.
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland. Acts by binding to oxytocin receptor
CC       (OXTR) (By similarity). {ECO:0000250|UniProtKB:P01178}.
CC   -!- SUBUNIT: Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
CC       Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222
CC       nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
CC       {ECO:0000250|UniProtKB:P01178}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; B90667; B90667.
DR   SMR; P69043; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   Pfam; PF00220; Hormone_4; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..9
FT                   /note="Oxytocin"
FT                   /id="PRO_0000044084"
FT   MOD_RES         9
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:5150741"
FT   DISULFID        1..6
FT                   /evidence="ECO:0000269|PubMed:5150741"
SQ   SEQUENCE   9 AA;  1010 MW;  17F8376EB456D04B CRC64;
     CYIQNCPLG