ID   NEU2_ANSAN              Reviewed;         131 AA.
AC   P19630;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Neurophysin 2;
DE   AltName: Full=MSEL-neurophysin;
OS   Anser anser anser (Western greylag goose).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anserinae; Anser.
OX   NCBI_TaxID=8844;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2279853; DOI=10.1111/j.1399-3011.1990.tb00983.x;
RA   Michel G., Levy B., Chauvet M.-T., Chauvet J., Acher R.;
RT   "Non-mammalian 'big' neurophysins -- complete amino acid sequence of a two-
RT   domain MSEL-neurophysin from goose.";
RL   Int. J. Pept. Protein Res. 36:302-307(1990).
CC   -!- FUNCTION: Neurophysin 2 specifically binds vasopressin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A43980; A43980.
DR   AlphaFoldDB; P19630; -.
DR   SMR; P19630; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   CHAIN           1..131
FT                   /note="Neurophysin 2"
FT                   /id="PRO_0000160938"
FT   DISULFID        10..55
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        13..27
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        21..45
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        28..35
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        62..74
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        68..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        75..80
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   131 AA;  13326 MW;  366376315E96E5FC CRC64;
     ALADTALRQC LPCGPGNRGR CFGPGICCGV ELGGCYVGTA ETRRCAEEDY LPSPCQPGGQ
     PCGSGGRCAA DGVCCSADTC AADASCLEEG SERAEEAAEK NLTVLDGSAG DLLLRLMQLA
     GRQQGRQPGL L