ID   NEU2_BALPH              Reviewed;         107 AA.
AC   P01184;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 92.
DE   RecName: Full=Vasopressin-neurophysin 2;
DE   Contains:
DE     RecName: Full=Arg-vasopressin;
DE     AltName: Full=Arginine-vasopressin;
DE   Contains:
DE     RecName: Full=Neurophysin 2;
DE   Flags: Precursor; Fragment;
GN   Name=AVP;
OS   Balaenoptera physalus (Fin whale) (Balaena physalus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9770;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-9, AND AMIDATION AT GLY-9.
RX   PubMed=14118277; DOI=10.1038/201191a0;
RA   Acher R., Chauvet J., Chauvet M.-T.;
RT   "Isolation of finback whale oxytocin and vasopressin.";
RL   Nature 201:191-192(1964).
RN   [2]
RP   PROTEIN SEQUENCE OF 13-107.
RX   PubMed=639997; DOI=10.1016/0014-5793(78)80614-0;
RA   Chauvet M.-T., Codogno P., Chauvet J., Acher R.;
RT   "Phylogeny of neurophysins: complete amino acid sequence of whale
RT   (Balaenoptera physalus) MSEL-neurophysin.";
RL   FEBS Lett. 88:91-93(1978).
CC   -!- FUNCTION: Neurophysin 2 specifically binds vasopressin.
CC   -!- FUNCTION: Vasopressin has a direct antidiuretic action on the kidney,
CC       it also causes vasoconstriction of the peripheral vessels. Acts by
CC       binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and
CC       V2R/AVPR2) (By similarity). {ECO:0000250|UniProtKB:P01185}.
CC   -!- SUBUNIT: Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM),
CC       V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity).
CC       Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).
CC       {ECO:0000250|UniProtKB:P01185}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: X's have been placed at positions 10-12 by homology with
CC       the complete sequence of the bovine precursor.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; B93147; NVWH2F.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted; Vasoactive; Vasoconstrictor.
FT   PEPTIDE         1..9
FT                   /note="Arg-vasopressin"
FT                   /id="PRO_0000020507"
FT   CHAIN           13..107
FT                   /note="Neurophysin 2"
FT                   /id="PRO_0000020508"
FT   SITE            9
FT                   /note="Important for agonist activity on V1aR/AVPR1A"
FT                   /evidence="ECO:0000250|UniProtKB:P01185"
FT   MOD_RES         9
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:14118277"
FT   DISULFID        1..6
FT   DISULFID        22..66
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        25..39
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        33..56
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        40..46
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        73..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        79..97
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        86..91
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   NON_TER         1
FT   NON_TER         107
SQ   SEQUENCE   107 AA;  11290 MW;  1E48830286092277 CRC64;
     CYFQNCPRGX XXAMSDLELR QCLPCGPGGK GRCFGPSICC GDELGCFMGT AEALRCQEEN
     YLPSPCQSGQ KPCGSGGRCA AAGICCNDES CVTEPECREG ASFPRRA