ID   NEU2_HORSE              Reviewed;          92 AA.
AC   P01182;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Neurophysin 2;
DE   Flags: Fragment;
GN   Name=AVP;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=891988; DOI=10.1016/0014-5793(77)80479-1;
RA   Chauvet M.-T., Codogno P., Chauvet J., Acher R.;
RT   "Phylogeny of the neurophysins: complete amino acid sequence of horse MSEL-
RT   neurophysin.";
RL   FEBS Lett. 80:374-376(1977).
CC   -!- FUNCTION: Neurophysin 2 specifically binds the midbrain peptide hormone
CC       vasopressin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A01444; NFHO2.
DR   AlphaFoldDB; P01182; -.
DR   SMR; P01182; -.
DR   STRING; 9796.ENSECAP00000044610; -.
DR   PaxDb; P01182; -.
DR   InParanoid; P01182; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031894; F:V1A vasopressin receptor binding; IBA:GO_Central.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Reference proteome; Secreted.
FT   CHAIN           <1..92
FT                   /note="Neurophysin 2"
FT                   /id="PRO_0000160936"
FT   DISULFID        7..51
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        10..24
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        18..41
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        25..31
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        58..70
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        64..82
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        71..76
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   NON_TER         1
SQ   SEQUENCE   92 AA;  9502 MW;  8B163CBE5D8C5CF8 CRC64;
     DLELRQCLPC GPGGKGRCFG PSICCGDELG CFVGTAEALR CQEENYLPSP CQSGQKPCGS
     GGRCAAAGIC CNDESCVTEP ECREGAGLPR RA