ID   NEU2_LOXAF              Reviewed;          92 AA.
AC   P81768;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Neurophysin 2;
DE   AltName: Full=E-NP;
DE   AltName: Full=Neurophysin-II;
GN   Name=AVP;
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Posterior pituitary;
RX   PubMed=7822104; DOI=10.1111/j.1399-3011.1994.tb00170.x;
RA   Huang H.-B., Wellner D., Naude R., Oelofsen W., Oosthuizen M.M.J.,
RA   Breslow E.;
RT   "Amino acid sequence and properties of vasopressin-associated elephant
RT   neurophysin.";
RL   Int. J. Pept. Protein Res. 44:270-277(1994).
CC   -!- FUNCTION: Neurophysin 2 specifically binds vasopressin.
CC   -!- SUBUNIT: There is an equilibrium between the monomeric and dimeric
CC       forms. On peptide binding the dimeric form predominates.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: A shorter neurophysin molecule (1-90) also exists and is probably
CC       derived from the complete protein by proteolytic degradation (in vivo
CC       or after extraction).
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   AlphaFoldDB; P81768; -.
DR   SMR; P81768; -.
DR   STRING; 9785.ENSLAFP00000005943; -.
DR   eggNOG; ENOG502S21K; Eukaryota.
DR   InParanoid; P81768; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Reference proteome; Secreted.
FT   CHAIN           1..92
FT                   /note="Neurophysin 2"
FT                   /id="PRO_0000160937"
FT   DISULFID        10..54
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        13..27
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        21..44
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        28..34
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        61..73
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        67..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        74..79
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   92 AA;  9543 MW;  1AB90023D44D6B18 CRC64;
     AMSDMELRQC LPCGPGGKGR CFGPSICCGE ELGCFVGTAE ALRCQEENYL PSPCQSGQKP
     CGSGGRCAAA GICCYEESCV TEPECREGAG IH