ID   NEU2_STRCA              Reviewed;         132 AA.
AC   P21916;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Neurophysin 2;
DE   AltName: Full=MSEL-neurophysin;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2722398; DOI=10.1111/j.1399-3011.1989.tb00682.x;
RA   Lazure C., Saayman H.S., Naude R.J., Oelofsen W., Chretien M.;
RT   "Ostrich MSEL-neurophysin belongs to the class of two-domain 'big'
RT   neurophysin as indicated by complete amino acid sequence of the
RT   neurophysin/copeptin.";
RL   Int. J. Pept. Protein Res. 33:46-58(1989).
CC   -!- FUNCTION: Neurophysin 2 specifically binds vasopressin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; A30978; A30978.
DR   AlphaFoldDB; P21916; -.
DR   SMR; P21916; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   CHAIN           1..132
FT                   /note="Neurophysin 2"
FT                   /id="PRO_0000160939"
FT   DISULFID        10..54
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        13..27
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        21..44
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        28..34
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        61..73
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        67..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        74..79
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   132 AA;  13363 MW;  D1BAC646D58CB33E CRC64;
     ALADAALRQC MPCGPGDRGN CFGPSICCGA ELGCYVGTAE TLRCAEENYL PSPCRAGGQP
     CGAGGRCAAP GICCSDETCS LEPACLEEAG ERGGEPAQKN LTGLDASAGD FLLKLMHLAA
     NRQQQGGKGP LL