ID   NEU3_CATCO              Reviewed;         152 AA.
AC   P17668;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Vasotocin-neurophysin VT 1;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT 1;
DE   Flags: Precursor;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2748582; DOI=10.1073/pnas.86.14.5242;
RA   Heierhorst J., Morley S.D., Figueroa J., Krentler C., Lederis K.,
RA   Richter D.;
RT   "Vasotocin and isotocin precursors from the white sucker, Catostomus
RT   commersoni: cloning and sequence analysis of the cDNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5242-5246(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1970742; DOI=10.1021/bi00462a011;
RA   Morley S.D., Schoenrock C., Heierhorst J., Figueroa J., Lederis K.,
RA   Richter D.;
RT   "Vasotocin genes of the teleost fish Catostomus commersoni: gene structure,
RT   exon-intron boundary, and hormone precursor organization.";
RL   Biochemistry 29:2506-2511(1990).
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M25144; AAA49198.1; -; mRNA.
DR   PIR; A32669; A32669.
DR   AlphaFoldDB; P17668; -.
DR   SMR; P17668; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT   PEPTIDE         20..28
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020548"
FT   CHAIN           32..152
FT                   /note="Neurophysin VT 1"
FT                   /id="PRO_0000020549"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..25
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        40..84
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        51..74
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        58..64
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        91..103
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        97..115
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        104..109
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   152 AA;  16009 MW;  8BF4885930B4939E CRC64;
     MSDSFLPTCI LCLLALSSAC YIQNCPRGGK RSQPDTSREC VSCGPGNAGR CYGPSICCGA
     ALGCLVGSPE TMSCMEENHL PSPCETGGRP CGDEGRCAAP GVCCDSVSCV MDSECLEDVR
     SDQSEDPSRL KTVSGEILLR LLNLASRGRR DF