ID   NEU3_EPTST              Reviewed;         161 AA.
AC   Q7M428;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Vasotocin-neurophysin VT;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT;
DE   Flags: Precursor;
OS   Eptatretus stoutii (Pacific hagfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Eptatretinae; Eptatretus.
OX   NCBI_TaxID=7765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=1379721; DOI=10.1073/pnas.89.15.6798;
RA   Heierhorst J., Lederis K., Richter D.;
RT   "Presence of a member of the Tc1-like transposon family from nematodes and
RT   Drosophila within the vasotocin gene of a primitive vertebrate, the Pacific
RT   hagfish Eptatretus stouti.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:6798-6802(1992).
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M93037; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; M93040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A46189; A46189.
DR   AlphaFoldDB; Q7M428; -.
DR   SMR; Q7M428; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..31
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020552"
FT   CHAIN           35..161
FT                   /note="Neurophysin VT"
FT                   /id="PRO_0000020553"
FT   MOD_RES         31
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..28
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        43..91
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        46..58
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        52..81
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        59..71
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        99..111
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        105..123
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        112..117
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   161 AA;  15812 MW;  EAFCA80501E84880 CRC64;
     MSAMGWTLLA AALLAISAQS NGCYIQNCPR GGKRAVETEL HSCAACGLGG QCVGPSICCG
     GLLGGGRGGG CIVGGPLSAP CKRENLHPEP CRPGGGSSCG LEGICAAPGI CCTDVTCSID
     ATCDDVTEKA GVTFSGATGG LANPTGDLLR KVLLLANADL E