ID   NEU3_ONCMA              Reviewed;         155 AA.
AC   Q07662;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Vasotocin-neurophysin VT 1;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT 1;
DE   Flags: Precursor;
OS   Oncorhynchus masou (Cherry salmon) (Masu salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=1369229;
RA   Suzuki M., Hyodo S., Urano A.;
RT   "Cloning and sequence analyses of vasotocin and isotocin precursor cDNAs in
RT   the masu salmon, Oncorhynchus masou: evolution of neurohypophysial hormone
RT   precursors.";
RL   Zool. Sci. 9:157-167(1992).
CC   -!- FUNCTION: Vasotocin is probably an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; D10945; BAA01739.1; -; mRNA.
DR   EMBL; S58720; AAC60743.1; -; mRNA.
DR   AlphaFoldDB; Q07662; -.
DR   SMR; Q07662; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         21..29
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020566"
FT   CHAIN           33..155
FT                   /note="Neurophysin VT 1"
FT                   /id="PRO_0000020567"
FT   MOD_RES         29
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..26
FT   DISULFID        41..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        52..75
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        59..65
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        92..105
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        99..117
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        106..111
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   155 AA;  16465 MW;  F052B4CE59D69620 CRC64;
     MPDSTIPLLC VLGLLALSSA CYIQNCPRGG KRSFPDLKRP CMSCGPGNRG LCFGPSICCG
     EGMGCYMGSP EAASCVEENY LTSPCEVGGR VCGSEEGHCA APGVCCDAES CLLDSDCLDD
     SKRQPPSEQY SSLMEGLAGD LLQWMLHATR RERPQ