ID   NEU4_CATCO              Reviewed;         155 AA.
AC   P16229;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Vasotocin-neurophysin VT 2;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT 2;
DE   Flags: Precursor;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1970742; DOI=10.1021/bi00462a011;
RA   Morley S.D., Schoenrock C., Heierhorst J., Figueroa J., Lederis K.,
RA   Richter D.;
RT   "Vasotocin genes of the teleost fish Catostomus commersoni: gene structure,
RT   exon-intron boundary, and hormone precursor organization.";
RL   Biochemistry 29:2506-2511(1990).
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; J02889; AAA49199.1; -; mRNA.
DR   PIR; B32669; B32669.
DR   AlphaFoldDB; P16229; -.
DR   SMR; P16229; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT   PEPTIDE         21..29
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020550"
FT   CHAIN           33..155
FT                   /note="Neurophysin VT 2"
FT                   /id="PRO_0000020551"
FT   REGION          119..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         29
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..26
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        42..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        45..59
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..76
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        60..66
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        93..106
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        100..118
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        107..112
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   155 AA;  16191 MW;  60DC462C057A8913 CRC64;
     MSVCAVLLLC VAGLLCLSSA CYIQNCPRGG KRALLEPVSR QCLACGPGDK GRCLGPSICC
     GEEIGCLVGS PWMARCQEEE YLPSPCQTAG KLCGSDAGPC AAPGVCCGTE GCKLDPNCSE
     DSESEEPADQ NTLGASPGEL LLRLLHPNNR KHNQY