ID   NEUA_HAEIN              Reviewed;         228 AA.
AC   Q57140; O05051;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable N-acylneuraminate cytidylyltransferase;
DE            EC=2.7.7.43;
DE   AltName: Full=CMP-N-acetylneuraminic acid synthase;
DE            Short=CMP-NeuNAc synthase;
DE   AltName: Full=CMP-sialic acid synthase;
GN   Name=neuA; OrderedLocusNames=HI_1279;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC         diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22927.1; -; Genomic_DNA.
DR   PIR; C64114; C64114.
DR   RefSeq; NP_439432.1; NC_000907.1.
DR   AlphaFoldDB; Q57140; -.
DR   SMR; Q57140; -.
DR   STRING; 71421.HI_1279; -.
DR   EnsemblBacteria; AAC22927; AAC22927; HI_1279.
DR   KEGG; hin:HI_1279; -.
DR   PATRIC; fig|71421.8.peg.1330; -.
DR   eggNOG; COG1083; Bacteria.
DR   HOGENOM; CLU_042930_1_0_6; -.
DR   OMA; AYHMKEL; -.
DR   PhylomeDB; Q57140; -.
DR   BioCyc; HINF71421:G1GJ1-1304-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR003329; Cytidylyl_trans.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF02348; CTP_transf_3; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..228
FT                   /note="Probable N-acylneuraminate cytidylyltransferase"
FT                   /id="PRO_0000213204"
SQ   SEQUENCE   228 AA;  25308 MW;  B3CC7674CA379551 CRC64;
     MKIIMTRIAI IPARAGSKGI KDKNLQLVGG VSLVGRAILA AQESGMFDQI VVTSDGENIL
     KEATKYGAKP VARPESLAQS DTRTIDAILH CLETLNISQG TAALLQPTSP LRNALDIRNA
     MEIFLGGKYK SVVSACECEH HPYKSFTLEG TEVQPIHELT DFESPRQKLP KSYRANGAIY
     INDIQSLFEE KRFFIAPMRF YLMPTYRSID IDSTLDLQLA ESLISKEF