ID   NEUC_ECOLX              Reviewed;         391 AA.
AC   Q47400;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Polysialic acid biosynthesis protein P7;
GN   Name=neuC;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-13.
RC   STRAIN=K1;
RX   PubMed=1729218; DOI=10.1128/jb.174.1.315-319.1992;
RA   Zapata G., Crowley J.M., Vann W.F.;
RT   "Sequence and expression of the Escherichia coli K1 neuC gene product.";
RL   J. Bacteriol. 174:315-319(1992).
CC   -!- FUNCTION: May be involved in the synthesis of polysialic acid (PSA).
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is 7.38.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M84026; AAA24211.1; -; Genomic_DNA.
DR   PIR; A43299; A43299.
DR   RefSeq; WP_000723250.1; NZ_WVVR01000003.1.
DR   AlphaFoldDB; Q47400; -.
DR   SMR; Q47400; -.
DR   OMA; VTYHPVT; -.
DR   BioCyc; MetaCyc:MON-14541; -.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR   GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro.
DR   InterPro; IPR020004; UDP-GlcNAc_Epase.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR03568; NeuC_NnaA; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:1729218"
FT   CHAIN           2..391
FT                   /note="Polysialic acid biosynthesis protein P7"
FT                   /id="PRO_0000096786"
SQ   SEQUENCE   391 AA;  44211 MW;  AF5004CC9FDAF468 CRC64;
     MKKILYVTGS RAEYGIVRRL LTMLRETPEI QLDLAVTGMH CDNAYGNTIH IIEQDNFNII
     KVVDININTT SHTHILHSMS VCLNSFGDFF SNNTYDAVMV LGDRYEIFSV AIAASMHNIP
     LIHIHGGEKT LANYDEFIRH SITKMSKLHL TSTEEYKKRV IQLGEKPGSV FNIGSLGAEN
     ALSLHLPNKQ ELELKYGSLL KRYFVVVFHP ETLSTQSVND QIDELLSAIS FFKNTHDFIF
     IGSNADTGSD IIQRKVKYFC KEYKFRYLIS IRSEDYLAMI KYSCGLIGNS SSGLIEVPSL
     KVATINIGDR QKGRVRGASV IDVPVEKNAI VRGINISQDE KFISVVQSSS NPYFKENALI
     NAVRIIKDFI KSKNKDYKDF YDIPECTTSY D