ID   NEUFC_CAEBR             Reviewed;         326 AA.
AC   Q60YT6; A8XT08;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Neuferricin homolog;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2 homolog;
DE   Flags: Precursor;
GN   Name=tag-131; ORFNames=CBG18095;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Heme-binding protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       136 and 169. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; HE600963; CAP35611.1; -; Genomic_DNA.
DR   RefSeq; XP_002642143.1; XM_002642097.1.
DR   AlphaFoldDB; Q60YT6; -.
DR   SMR; Q60YT6; -.
DR   STRING; 6238.CBG18095; -.
DR   EnsemblMetazoa; CBG18095.1; CBG18095.1; WBGene00037581.
DR   GeneID; 8584138; -.
DR   KEGG; cbr:CBG_18095; -.
DR   CTD; 8584138; -.
DR   WormBase; CBG18095; CBP04346; WBGene00037581; Cbr-tag-131.
DR   eggNOG; KOG1108; Eukaryota.
DR   HOGENOM; CLU_065455_0_0_1; -.
DR   InParanoid; Q60YT6; -.
DR   OMA; GHKHYGP; -.
DR   OrthoDB; 1355837at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..326
FT                   /note="Neuferricin homolog"
FT                   /id="PRO_0000312326"
FT   DOMAIN          98..197
FT                   /note="Cytochrome b5 heme-binding"
SQ   SEQUENCE   326 AA;  36252 MW;  D8D3A5983C50A378 CRC64;
     MEKNRRKKDD AGVMTKTLAG VAALTFLVSF ICSSYDITFS HVISTIDVIL EESEYYRSTK
     EWMASSIDAT WHEVSIPSRK AEHLQAINPE VDVAAGGKHV FTPEQLHFFD GSRDSKPCYL
     AILGRVYDVD GKKEYYGPGK SYHHFAGRDA TRAFTTGDFT ENGLVASTHG LSHDELLSIR
     DWVSFYDKEY PLVGVVADLY YDSDGQPTAE LTDVLARVEK ANEYRKAQAV EIEVFPPCNS
     EYNQNGGRVW CSTKSGGVER QWAGVPRKLI EQTTKKFRCA CVKNFGPGVS GAEEVKTSSN
     RGDLDHPDLE LFPDCSPTSN SCKIVS