ID   NEUFC_CAEEL             Reviewed;         326 AA.
AC   Q9XXA7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Neuferricin homolog;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2 homolog;
DE   Flags: Precursor;
GN   Name=tag-131; ORFNames=H38K22.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Heme-binding protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       136 and 169. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL024499; CAA19709.1; -; Genomic_DNA.
DR   PIR; T23139; T23139.
DR   RefSeq; NP_497868.1; NM_065467.3.
DR   AlphaFoldDB; Q9XXA7; -.
DR   SMR; Q9XXA7; -.
DR   BioGRID; 40793; 2.
DR   STRING; 6239.H38K22.3; -.
DR   EPD; Q9XXA7; -.
DR   PaxDb; Q9XXA7; -.
DR   PeptideAtlas; Q9XXA7; -.
DR   PRIDE; Q9XXA7; -.
DR   EnsemblMetazoa; H38K22.3.1; H38K22.3.1; WBGene00006478.
DR   GeneID; 175557; -.
DR   KEGG; cel:CELE_H38K22.3; -.
DR   UCSC; H38K22.3; c. elegans.
DR   CTD; 175557; -.
DR   WormBase; H38K22.3; CE18831; WBGene00006478; tag-131.
DR   eggNOG; KOG1108; Eukaryota.
DR   GeneTree; ENSGT00940000160156; -.
DR   HOGENOM; CLU_065455_0_0_1; -.
DR   InParanoid; Q9XXA7; -.
DR   OMA; GHKHYGP; -.
DR   OrthoDB; 1355837at2759; -.
DR   PhylomeDB; Q9XXA7; -.
DR   PRO; PR:Q9XXA7; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006478; Expressed in embryo and 4 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..326
FT                   /note="Neuferricin homolog"
FT                   /id="PRO_0000312327"
FT   DOMAIN          98..197
FT                   /note="Cytochrome b5 heme-binding"
SQ   SEQUENCE   326 AA;  36242 MW;  F67A0D28D176C8CE CRC64;
     MDKNRRRTDD AGLMTKTLAG IAALVFFLSF ICSSYDITVT HVISTIDVIL EESEYYRSAK
     EWTASSIDAT WNEVSIPSRK AEHIQAINPE VDVAAGGKHV FTPEQLHFFD GTRDSKPIYL
     AILGRVYNVD GKKEYYGPGK SYHHFAGRDA TRAFTTGDFQ ESGLIATTHG LSHDELLSIR
     DWVSFYDKEY PLVGVVADLY YDSEGQPTPE LTDVLARVEK ANEYRKAQAV EIEVFPPCNS
     EYNQNGGRVW CSTKSGGVER QWAGVPRKLI EPTTEKFRCA CVKNFGPGVS GAEEVKSSSN
     RGDLDHPDLE LFPDCSPTSN SCKIVS