ID   NEUFC_DANRE             Reviewed;         267 AA.
AC   A2CES0;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Neuferricin;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=cyb5d2; ORFNames=si:ch211-117m20.9;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Heme-binding protein which promotes neuronal but not
CC       astrocyte differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       90 and 114. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR753844; CAM15241.1; -; Genomic_DNA.
DR   RefSeq; NP_001096144.1; NM_001102674.1.
DR   AlphaFoldDB; A2CES0; -.
DR   SMR; A2CES0; -.
DR   STRING; 7955.ENSDARP00000080969; -.
DR   PaxDb; A2CES0; -.
DR   Ensembl; ENSDART00000086534; ENSDARP00000080969; ENSDARG00000061006.
DR   GeneID; 795950; -.
DR   KEGG; dre:795950; -.
DR   CTD; 124936; -.
DR   ZFIN; ZDB-GENE-050506-83; cyb5d2.
DR   eggNOG; KOG1108; Eukaryota.
DR   GeneTree; ENSGT00940000160156; -.
DR   HOGENOM; CLU_065455_2_0_1; -.
DR   InParanoid; A2CES0; -.
DR   OMA; GHKHYGP; -.
DR   OrthoDB; 1355837at2759; -.
DR   PhylomeDB; A2CES0; -.
DR   TreeFam; TF313943; -.
DR   PRO; PR:A2CES0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000061006; Expressed in mature ovarian follicle and 21 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   3: Inferred from homology;
KW   Neurogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..267
FT                   /note="Neuferricin"
FT                   /id="PRO_0000312324"
FT   DOMAIN          53..150
FT                   /note="Cytochrome b5 heme-binding"
SQ   SEQUENCE   267 AA;  29715 MW;  0F6AF19C65CD0D1F CRC64;
     MLKYLVALIS MVLAVWTVPE WLTFPIYGNV VTVLESWLRQ RVSEVSASSP GLLLTKEQLS
     LYNGGKNSKG LYLAILGQVF DVEKGRKHYG PGGGYHFFTG KDASRAFITG DFTEAGLSND
     VSDFSESQIV ALYDWLSFYQ RDYTPVGKLI GRFYTETGQP TDALLHVEAF LSDGLKKKAQ
     AQSEMQLYPS CNSEWSEASG GRVWCSTMSG GIHRDWVGVP RMLFTPGSGH SRCVCIRLSD
     PVHSENRNLR EYTDCPPRAE SCQIAKD