ID   NEUFC_DROPS             Reviewed;         286 AA.
AC   Q29HF1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Neuferricin homolog;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2 homolog;
DE   Flags: Precursor;
GN   ORFNames=GA11364;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Heme-binding protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       98 and 125. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CH379064; EAL31807.1; -; Genomic_DNA.
DR   RefSeq; XP_001354752.1; XM_001354716.3.
DR   AlphaFoldDB; Q29HF1; -.
DR   SMR; Q29HF1; -.
DR   STRING; 7237.FBpp0282824; -.
DR   EnsemblMetazoa; FBtr0284386; FBpp0282824; FBgn0071418.
DR   GeneID; 4814739; -.
DR   KEGG; dpo:Dpse_GA11364; -.
DR   eggNOG; KOG1108; Eukaryota.
DR   HOGENOM; CLU_065455_0_1_1; -.
DR   InParanoid; Q29HF1; -.
DR   OMA; IELAKWQ; -.
DR   PhylomeDB; Q29HF1; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0071418; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..286
FT                   /note="Neuferricin homolog"
FT                   /id="PRO_0000312329"
FT   DOMAIN          61..145
FT                   /note="Cytochrome b5 heme-binding"
FT   COILED          176..200
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   286 AA;  32439 MW;  1EB99BF8CB6F3919 CRC64;
     MFGFVKYLFK LQFLFILAAV LAGLYRTEIK QFANRHAANY VDKADVETVS LQFKAANENT
     ATVLTSAELS KYNGEDGQPI YLALLGSVFD VTRGIKHYGT GCSYNFFVGR DASVAFISGE
     FEEYDPQTAD DVLTLKPNDL LGLANWRDFY EKEYIYKGKL IGRFYDEQGE PTTYYHKYLA
     LLEQAQIAKA EVDELRSKYP GCNIEWSEAK GTRVWCTNTS GDGKERAWTG FPRKLYSRGN
     KNFNCACVPE SELDQIDAEG QAAHGDVMFK TYDNCSSRAK ECFYRV