ID   NEUFC_RAT               Reviewed;         263 AA.
AC   Q6AY62;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Neuferricin;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=Cyb5d2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Heme-binding protein which promotes neuronal but not
CC       astrocyte differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       73 and 106. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC       extranuclear signaling are classified in 2 groups: the class II
CC       progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC       PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC       protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC       {ECO:0000250|UniProtKB:Q8WUJ1}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC079177; AAH79177.1; -; mRNA.
DR   RefSeq; NP_001007672.1; NM_001007671.1.
DR   AlphaFoldDB; Q6AY62; -.
DR   SMR; Q6AY62; -.
DR   STRING; 10116.ENSRNOP00000038452; -.
DR   PaxDb; Q6AY62; -.
DR   PRIDE; Q6AY62; -.
DR   Ensembl; ENSRNOT00000036942; ENSRNOP00000038452; ENSRNOG00000024553.
DR   GeneID; 303293; -.
DR   KEGG; rno:303293; -.
DR   CTD; 124936; -.
DR   RGD; 1359124; Cyb5d2.
DR   eggNOG; KOG1108; Eukaryota.
DR   GeneTree; ENSGT00940000160156; -.
DR   HOGENOM; CLU_065455_2_0_1; -.
DR   InParanoid; Q6AY62; -.
DR   OMA; GHKHYGP; -.
DR   OrthoDB; 1355837at2759; -.
DR   PhylomeDB; Q6AY62; -.
DR   TreeFam; TF313943; -.
DR   PRO; PR:Q6AY62; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000024553; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   2: Evidence at transcript level;
KW   Neurogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..263
FT                   /note="Neuferricin"
FT                   /id="PRO_0000312323"
FT   DOMAIN          35..134
FT                   /note="Cytochrome b5 heme-binding"
FT   REGION          219..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29065 MW;  57CBF0F66D455159 CRC64;
     MLRICGLGVV LSLAVAAAAV LAVWLMDWWG SHPSIRLFVP EELARYRGGP GDPGLYLALL
     GRVYDVSSGR KHYEPGAHYS GFAGRDASRA FVTGDYSEAG LVDDVNGLSS SEILTLHNWL
     SFYEKNYVFV GRLIGRFYGK DGLPTSELTQ VEAMVTKGME ANEQEQREKQ RFPPCNAEWS
     SAKGSRLWCS QKSGGVHRDW IGVPRKLYKP GAKEPHCVCV RTTGPPSDQQ DNPRHSNRGD
     LDNPNLEEYT GCPPLAVTCF FPL