ID   NEUFC_XENTR             Reviewed;         273 AA.
AC   Q28FI8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Neuferricin;
DE   AltName: Full=Cytochrome b5 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=cyb5d2; ORFNames=TNeu100j22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Heme-binding protein which promotes neuronal but not
CC       astrocyte differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The cytochrome b5 heme-binding domain was proven to bind heme,
CC       although it lacks the conserved iron-binding His residues at position
CC       82 and 124. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR761951; CAJ82785.1; -; mRNA.
DR   RefSeq; NP_001016154.1; NM_001016154.1.
DR   AlphaFoldDB; Q28FI8; -.
DR   SMR; Q28FI8; -.
DR   STRING; 8364.ENSXETP00000039513; -.
DR   PaxDb; Q28FI8; -.
DR   Ensembl; ENSXETT00000039513; ENSXETP00000039513; ENSXETG00000018225.
DR   GeneID; 548908; -.
DR   KEGG; xtr:548908; -.
DR   CTD; 124936; -.
DR   Xenbase; XB-GENE-981419; cyb5d2.
DR   eggNOG; KOG1108; Eukaryota.
DR   HOGENOM; CLU_065455_0_0_1; -.
DR   InParanoid; Q28FI8; -.
DR   OMA; GHKHYGP; -.
DR   OrthoDB; 1355837at2759; -.
DR   PhylomeDB; Q28FI8; -.
DR   TreeFam; TF313943; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018225; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q28FI8; baseline.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; -; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; SSF55856; 1.
PE   2: Evidence at transcript level;
KW   Neurogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..273
FT                   /note="Neuferricin"
FT                   /id="PRO_0000312325"
FT   DOMAIN          44..143
FT                   /note="Cytochrome b5 heme-binding"
SQ   SEQUENCE   273 AA;  30527 MW;  85D9BCA013F8C332 CRC64;
     MLGYLAAAAL CLAAVLLMRL DHLPLVDIPG LGYIFPQQCE LSEGRLMSKE ELSVYDGGPG
     SSGIYLAILG QVFDVHKGSK HYGPGGSYSF FAGKDASRAY MTGDFTEKGL VDDVTELSPL
     QMLHLHNWLS FYQQNYITIG KLTGRFYDES GNPTKALEDA LKVIDIGLKL KEEREEENKQ
     FPPCNSEWSS ESKRVWCSKN SGGIQRDWVG VPRKMYTAGT NGYRCVCVRN FGPPSEQPDS
     TEHNDRGDLD NPMLHEYEDC NPLFEWCFLK NGT