NEUG_SERCA
ID NEUG_SERCA Reviewed; 73 AA.
AC P54866;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Neurogranin;
DE Short=NG;
DE AltName: Full=Canarigranin;
GN Name=NRGN; Synonyms=HAT14;
OS Serinus canaria (Island canary) (Fringilla canaria).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae;
OC Carduelinae; Serinus.
OX NCBI_TaxID=9135;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wasserschlager;
RA George J.M., Siepka S.M., Jin H., Holloway C.C., Clayton D.F.;
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a 'third messenger' substrate of protein kinase C-
CC mediated molecular cascades during synaptic development and remodeling.
CC Binds to calmodulin in the absence of calcium (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurogranin family. {ECO:0000305}.
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DR EMBL; U56726; AAB01224.1; -; mRNA.
DR RefSeq; XP_009096054.1; XM_009097806.2.
DR AlphaFoldDB; P54866; -.
DR SMR; P54866; -.
DR Ensembl; ENSSCAT00000026778; ENSSCAP00000024069; ENSSCAG00000017228.
DR GeneID; 103822794; -.
DR KEGG; scan:103822794; -.
DR CTD; 4900; -.
DR GeneTree; ENSGT00440000039324; -.
DR OMA; KSKDPEC; -.
DR OrthoDB; 1639997at2759; -.
DR Proteomes; UP000694409; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; Phosphoprotein; Reference proteome.
FT CHAIN 1..73
FT /note="Neurogranin"
FT /id="PRO_0000159594"
FT DOMAIN 26..55
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 47..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine; by PKC"
FT /evidence="ECO:0000250"
SQ SEQUENCE 73 AA; 7853 MW; 01AD068CD461CC54 CRC64;
MDCCNEGACT KLDEDILDIP LDDPDANAAA AKIQASFRGH MTRKKIKGGE IDRKTKDAEC
ANSTRGGDLR NGD