ID   NEUI_TAKRU              Reviewed;         155 AA.
AC   O42493;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Isotocin-neurophysin IT 1;
DE   Contains:
DE     RecName: Full=Isotocin;
DE              Short=IT;
DE   Contains:
DE     RecName: Full=Neurophysin IT 1;
DE   Flags: Precursor;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8714027;
RA   Venkatesh B., Brenner S.;
RT   "Structure and organization of the isotocin and vasotocin genes from
RT   teleosts.";
RL   Adv. Exp. Med. Biol. 395:629-638(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9356472; DOI=10.1073/pnas.94.23.12462;
RA   Venkatesh B., Si-Hoe S.L., Murphy D., Brenner S.;
RT   "Transgenic rats reveal functional conservation of regulatory controls
RT   between the Fugu isotocin and rat oxytocin genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:12462-12466(1997).
CC   -!- FUNCTION: Isotocin causes contraction of smooth muscles.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U90880; AAC60289.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42493; -.
DR   SMR; O42493; -.
DR   STRING; 31033.ENSTRUP00000039963; -.
DR   eggNOG; ENOG502S2CT; Eukaryota.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         20..28
FT                   /note="Isotocin"
FT                   /id="PRO_0000020554"
FT   CHAIN           32..155
FT                   /note="Neurophysin IT 1"
FT                   /id="PRO_0000020555"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..25
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        41..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        52..75
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        59..65
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        92..105
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        99..117
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        106..111
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   155 AA;  16026 MW;  C73432D910141848 CRC64;
     MTGTAISVCL LFLLSVCSAC YISNCPIGGK RSIMDAPQRK CMSCGPGDRG RCFGPGICCG
     ESFGCLMGSP ESARCAEENY LLTPCQAGGR PCGSEGGLCA SSGLCCDAES CTMDQSCLSE
     EEGDERGSLF DGSDSGDVIL KLLRLAGLTS PHQTH