NEUL3_HUMAN
ID NEUL3_HUMAN Reviewed; 262 AA.
AC Q96EH8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=E3 ubiquitin-protein ligase NEURL3;
DE EC=2.3.2.27;
DE AltName: Full=Lung-inducible neuralized-related C3CH4 RING domain protein;
DE AltName: Full=Neuralized-like protein 3;
DE AltName: Full=RING-type E3 ubiquitin transferase NEURL3 {ECO:0000305};
GN Name=NEURL3; Synonyms=LINCR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-158.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In
CC vitro, generates polyubiquitin chains via non-canonical lysine residues
CC suggesting that it is not involved in tagging substrates for
CC proteasomal degradation. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC013270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK311953; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS74542.1; -.
DR RefSeq; NP_001272414.1; NM_001285485.1.
DR RefSeq; XP_011510480.1; XM_011512178.2.
DR RefSeq; XP_011510481.1; XM_011512179.2.
DR AlphaFoldDB; Q96EH8; -.
DR SMR; Q96EH8; -.
DR BioGRID; 124999; 3.
DR STRING; 9606.ENSP00000478591; -.
DR PhosphoSitePlus; Q96EH8; -.
DR BioMuta; NEURL3; -.
DR DMDM; 172045848; -.
DR MassIVE; Q96EH8; -.
DR PeptideAtlas; Q96EH8; -.
DR PRIDE; Q96EH8; -.
DR ProteomicsDB; 76409; -.
DR Antibodypedia; 74844; 27 antibodies from 8 providers.
DR DNASU; 93082; -.
DR Ensembl; ENST00000451794.6; ENSP00000478591.1; ENSG00000163121.10.
DR GeneID; 93082; -.
DR KEGG; hsa:93082; -.
DR MANE-Select; ENST00000451794.6; ENSP00000478591.1; NM_001285485.2; NP_001272414.1.
DR UCSC; uc010yup.3; human.
DR CTD; 93082; -.
DR DisGeNET; 93082; -.
DR GeneCards; NEURL3; -.
DR HGNC; HGNC:25162; NEURL3.
DR HPA; ENSG00000163121; Group enriched (kidney, pancreas, salivary gland).
DR neXtProt; NX_Q96EH8; -.
DR OpenTargets; ENSG00000163121; -.
DR VEuPathDB; HostDB:ENSG00000163121; -.
DR eggNOG; KOG4625; Eukaryota.
DR GeneTree; ENSGT00940000162540; -.
DR HOGENOM; CLU_090535_0_0_1; -.
DR InParanoid; Q96EH8; -.
DR OMA; PVCRWEI; -.
DR OrthoDB; 1384219at2759; -.
DR PhylomeDB; Q96EH8; -.
DR PathwayCommons; Q96EH8; -.
DR SignaLink; Q96EH8; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 93082; 1 hit in 163 CRISPR screens.
DR GenomeRNAi; 93082; -.
DR Pharos; Q96EH8; Tdark.
DR PRO; PR:Q96EH8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96EH8; protein.
DR Bgee; ENSG00000163121; Expressed in nasal cavity epithelium and 130 other tissues.
DR ExpressionAtlas; Q96EH8; baseline and differential.
DR Genevisible; Q96EH8; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12429; PTHR12429; 1.
DR Pfam; PF07177; Neuralized; 1.
DR SMART; SM00588; NEUZ; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS51065; NHR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Transferase; Ubl conjugation pathway;
KW Zinc; Zinc-finger.
FT CHAIN 1..262
FT /note="E3 ubiquitin-protein ligase NEURL3"
FT /id="PRO_0000325771"
FT DOMAIN 17..173
FT /note="NHR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT ZN_FING 202..241
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 81
FT /note="T -> A (in Ref. 2; AK311953)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 28789 MW; 215410351139F515 CRC64;
MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER
VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG
DLVRFWVDRR GCLFAKVNAG CRLLLREGVP VGAPLWAVMD VYGTTKAIEL LDPTASRLPT
PMPWDLSNKA VPEPKATPGE ECAICFYHAA NTRLVPCGHT YFCRYCAWRV FSDTAKCPVC
RWQIEAVAPA QGPPALRVEE GS
