NEUL3_RAT
ID NEUL3_RAT Reviewed; 254 AA.
AC Q5M870;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=E3 ubiquitin-protein ligase NEURL3;
DE EC=2.3.2.27;
DE AltName: Full=Lung-inducible neuralized-related C3CH4 RING domain protein;
DE AltName: Full=Neuralized-like protein 3;
DE AltName: Full=RING-type E3 ubiquitin transferase NEURL3 {ECO:0000305};
GN Name=Neurl3; Synonyms=Lincr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In
CC vitro, generates polyubiquitin chains via non-canonical lysine residues
CC suggesting that it is not involved in tagging substrates for
CC proteasomal degradation. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27;
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC088198; AAH88198.1; -; mRNA.
DR RefSeq; NP_001014122.1; NM_001014100.1.
DR RefSeq; XP_008765247.1; XM_008767025.2.
DR RefSeq; XP_008765248.1; XM_008767026.1.
DR AlphaFoldDB; Q5M870; -.
DR SMR; Q5M870; -.
DR STRING; 10116.ENSRNOP00000029092; -.
DR PaxDb; Q5M870; -.
DR Ensembl; ENSRNOT00000038610; ENSRNOP00000029092; ENSRNOG00000015366.
DR GeneID; 316326; -.
DR KEGG; rno:316326; -.
DR UCSC; RGD:1359633; rat.
DR CTD; 93082; -.
DR RGD; 1359633; Neurl3.
DR eggNOG; KOG4625; Eukaryota.
DR GeneTree; ENSGT00940000162540; -.
DR HOGENOM; CLU_090535_0_0_1; -.
DR InParanoid; Q5M870; -.
DR OMA; PVCRWEI; -.
DR OrthoDB; 1384219at2759; -.
DR PhylomeDB; Q5M870; -.
DR TreeFam; TF314368; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q5M870; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000015366; Expressed in ileum and 16 other tissues.
DR Genevisible; Q5M870; RN.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISO:RGD.
DR GO; GO:0016567; P:protein ubiquitination; ISO:RGD.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12429; PTHR12429; 1.
DR Pfam; PF07177; Neuralized; 1.
DR SMART; SM00588; NEUZ; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS51065; NHR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Transferase; Ubl conjugation pathway;
KW Zinc; Zinc-finger.
FT CHAIN 1..254
FT /note="E3 ubiquitin-protein ligase NEURL3"
FT /id="PRO_0000325773"
FT DOMAIN 17..174
FT /note="NHR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT ZN_FING 197..236
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 254 AA; 28014 MW; 41316CB3D09D0938 CRC64;
MGSRLSPEAN AEVPREALSF HGDATGAQVH LDDQRSTARR RSTFHDGIVF SQRPVWPGER
VALRVLRHED GWCGGLRVGF TRLDPAQVAA SCLPPFVCPD LEEQSPTWAA LLPEGFVRAG
NVVCFWVNRR GWLFAKVNAG RPLLLRKDVL VQGAPLWAVM DVYGTTKAIE LLDPKANAWI
TSGEPMPESE VTSGEECVIC FHNTANTRLM PCGHSQFCGS CAWHIFKDTA RCPMCRWQIE
EVAVEPSVKS GEGS
