ID   NEUL4_XENTR             Reviewed;        1477 AA.
AC   A1L0Y2;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Neuralized-like protein 4;
GN   Name=neurl4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes CCP110 ubiquitination and proteasome-dependent
CC       degradation. By counteracting accumulation of CP110, maintains normal
CC       centriolar homeostasis and preventing formation of ectopic microtubular
CC       organizing centers (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. This ubiquitination leads to proteasomal
CC       degradation (By similarity). {ECO:0000250}.
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DR   EMBL; BC127281; AAI27282.1; -; mRNA.
DR   RefSeq; NP_001090721.1; NM_001097252.1.
DR   AlphaFoldDB; A1L0Y2; -.
DR   SMR; A1L0Y2; -.
DR   PaxDb; A1L0Y2; -.
DR   GeneID; 100036703; -.
DR   KEGG; xtr:100036703; -.
DR   CTD; 84461; -.
DR   Xenbase; XB-GENE-5825550; neurl4.
DR   eggNOG; KOG4625; Eukaryota.
DR   InParanoid; A1L0Y2; -.
DR   OrthoDB; 74097at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017842; Expressed in gastrula and 13 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   Gene3D; 2.60.120.920; -; 6.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR037962; Neuralized.
DR   InterPro; IPR006573; NHR_dom.
DR   PANTHER; PTHR12429; PTHR12429; 1.
DR   Pfam; PF07177; Neuralized; 6.
DR   SMART; SM00588; NEUZ; 6.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51065; NHR; 6.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome; Repeat; Ubl conjugation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..1477
FT                   /note="Neuralized-like protein 4"
FT                   /id="PRO_0000299107"
FT   DOMAIN          1..167
FT                   /note="NHR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          250..417
FT                   /note="NHR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          450..616
FT                   /note="NHR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          645..813
FT                   /note="NHR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          841..1010
FT                   /note="NHR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          1048..1211
FT                   /note="NHR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1012..1041
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1477 AA;  160373 MW;  23805E3E8E237EC3 CRC64;
     MAELHPRTGK LISLSNGNRT AARKQPAQEF NQGLVVSARP LGPGEVFTVR LDRKMNSWSG
     SMEIGLTTQD PAFLDFPSSA TGLKGGSWIV SGCSVLEDGR SVLEEYGQDL DQLGEGDRVG
     VQRSISGELH LWVNGRDCGA ASCGIPPRVW AVVDLYGKCT QITVLSCQPP PEEEEEEDAE
     EQEGSLVPLG QSRPDKFPNS LDTDSGFPST ELSAVVSNAI LSAYHGSLLS VSLGSPPAAI
     EHSPPTCNDA LLFHEKCGTL IKLSNGNKTA ERRRPLDEFN NGVVMTNRPL RDCEMFEIRI
     DKLVDKWSGS IEIGVTTHNP NSLEYPATMT NLRSGTIMMS GCGILTNGKG TRREYCEFSL
     DELQEGDHIG LTRKSSGALH FYINGMDQGV ASCQTPPVVY GVVDLYGMAV KVTIVHNHNH
     ADRLRRNNAI LRARSPDTGR HSSSTPEPGQ LLFHSNCGQK ASIINGGRTA LRPHATDDFN
     HGVVLSNRPL QNNEVFQVRI DKMVDKWAGS IEIGVTTHNP AYLQLPSTMT NLRSGTWMMT
     GNGVMHNGTT ILDEYGHNLD RLKAGDTVGV VRREDGTLNF FVNGIAQGVA AWNVPPNVFA
     VVDLYGQAAQ ATIMDESDAL PLPGDEDEGL ALTPGTPCAL LSLSDLRFHH LHGANALITN
     GGRTVLRKNS RSEFNDAIVM SSRPLRDGEM FEIVIQKMVD RWSGSIEAGV TAIRPEDLEF
     PNTMTDIDYD TWMLSGTAIM QDGNTLRNNY GCDLDSLGAG SRIGMMKTIR GDLHYFINGE
     DQGVACTGLP MGRDIYAVID LYGQCVQVSL TGGSGLVDNS LSASHVTDKS LPSQSPVPSV
     SHRFHTVCGK NVSVLCDGTR AERGAGCSHG IVFSSRELLT NETFEIRVEK IEPHWSGSCN
     IGVTSLSPHE VSLLGGGLPE RALELRSKVT WLVCGSEVTR NGQRLRENYC NSLERVRVGS
     RLGVRRDSDD TLHILMNGED MGPAACGIPK AVYAVLDIHG CITALSTVSS SLLEEPDATK
     PPSITSESEE EEDPADHGDP HTVIQAHSLQ FLANHGKNIL LSHGNRTATR VSSYNQGIVV
     LPQPLPRLFL FQIRIDQLSP HWTSSLSIGV IAVSPERLNF PATAAALKRS SWIFQRSAVL
     CNGVKIREGY GPNLDLCPEG TCLGLLLDSS GGLHLYVNGL DQGVGAQDLP EVCYVLVDLY
     GQCEQVSIVT GEAQGAELDA HEGQLPGERE KADMVDGVKE SLCWVPPDPV ALLSCEYLAL
     CTRFKDLLLL PDGYFLEDSK LCVCHCDSCH KLRGDETYRK RGDPPREYAE PIGWCSFPLR
     LSPRSSCAQY KKWHIAYQGS SAGTIRRTLD RGDLLPGSAC ILTSVPAKSD PQSGFPAAEP
     NVLPPRDLQS VVLSPTLRYA ALPEMCPKVM FRDPRSQRMF GAQVALQVCV RPGSYKTGPP
     SACAIDLMDP RIPSSEMEFL TKEKGATVLR GLLVRVE