ID   NEUM_BUFJA              Reviewed;         125 AA.
AC   P08162;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mesotocin-neurophysin MT;
DE   Contains:
DE     RecName: Full=Mesotocin;
DE              Short=MT;
DE   Contains:
DE     RecName: Full=Neurophysin MT;
DE   Flags: Precursor;
OS   Bufo japonicus (Japanese toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo.
OX   NCBI_TaxID=8387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3033676; DOI=10.1073/pnas.84.9.3043;
RA   Nojiri H., Ishida I., Miyashita E., Sato M., Urano A., Deguchi T.;
RT   "Cloning and sequence analysis of cDNAs for neurohypophysial hormones
RT   vasotocin and mesotocin for the hypothalamus of toad, Bufo japonicus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:3043-3046(1987).
CC   -!- FUNCTION: Mesotocin is a diuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mesotocin is produced by magnocellular preoptic
CC       neurons in the hypothalamus in amphibians, reptiles and birds.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M16232; AAA48555.1; -; mRNA.
DR   PIR; A29879; A29879.
DR   AlphaFoldDB; P08162; -.
DR   SMR; P08162; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT   PEPTIDE         20..28
FT                   /note="Mesotocin"
FT                   /id="PRO_0000020530"
FT   CHAIN           32..125
FT                   /note="Neurophysin MT"
FT                   /id="PRO_0000020531"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..25
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        42..86
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        45..59
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..76
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        60..66
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        93..106
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        100..118
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        107..112
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   125 AA;  13516 MW;  D249A61F5A65B9B6 CRC64;
     MSYTALAVTF FGWLALSSAC YIQNCPIGGK RSVIDFMDVR KCIPCGPRNK GHCFGPNICC
     GEELGCYFGT TETLRCQEEN FLPSPCESGR KPCGNNGGNC ARSGICCNHE SCTMDPACEQ
     DSVFS