ID   NEUPP_BOMMO             Reviewed;         372 AA.
AC   B9WZ56;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Putative neuropeptide precursor protein {ECO:0000303|PubMed:19540422};
DE            Short=BmK5 {ECO:0000303|PubMed:19540422};
DE   Flags: Precursor;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAH22627.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=p50T; TISSUE=Subesophageal ganglion;
RX   PubMed=19540422; DOI=10.1016/j.peptides.2009.03.023;
RA   Mitsumasu K., Tanaka Y., Niimi T., Yamashita O., Yaginuma T.;
RT   "Novel gene encoding precursor protein consisting of possible several
RT   neuropeptides expressed in brain and frontal ganglion of the silkworm,
RT   Bombyx mori.";
RL   Peptides 30:1233-1240(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19540422,
CC       ECO:0000305}. Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in the brain and frontal ganglion and in
CC       the axons connecting to the corpus cardiacum and corpus allatum (at
CC       protein level). Detected in the brain-subesophageal ganglion (brain-SG)
CC       complex, fat body, midgut and ovary. Expression in the brain-SG complex
CC       is 2-3 times higher than in the other tissues.
CC       {ECO:0000269|PubMed:19540422}.
CC   -!- DEVELOPMENTAL STAGE: Detected at low levels in newly hatched larvae
CC       with higher levels in the fifth instar larvae which continue into the
CC       early and middle pupal stages. Expression then decreases by 6-day-old
CC       pupal stage and reduces further in the adult stage (at protein level).
CC       Expressed in the embryonic, larval and pupal-adult development stages.
CC       Detected in male embryos 6 days after oviposition with expression in
CC       female embryos starting later around day 8.
CC       {ECO:0000269|PubMed:19540422}.
CC   -!- PTM: May be proteolytically processed to give rise to a number of
CC       active peptides. {ECO:0000303|PubMed:19540422}.
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DR   EMBL; AB162718; BAH22627.1; -; mRNA.
DR   RefSeq; NP_001153662.1; NM_001160190.1.
DR   AlphaFoldDB; B9WZ56; -.
DR   SMR; B9WZ56; -.
DR   STRING; 7091.BGIBMGA008978-TA; -.
DR   EnsemblMetazoa; BGIBMGA008978-RA; BGIBMGA008978-TA; BGIBMGA008978.
DR   GeneID; 100301494; -.
DR   KEGG; bmor:100301494; -.
DR   CTD; 100301494; -.
DR   eggNOG; ENOG502TB3T; Eukaryota.
DR   HOGENOM; CLU_750637_0_0_1; -.
DR   InParanoid; B9WZ56; -.
DR   OMA; ENWDQTK; -.
DR   OrthoDB; 980077at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..372
FT                   /note="Putative neuropeptide precursor protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000412719"
FT   REGION          18..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  42011 MW;  715296DBB3C8DDCF CRC64;
     MLLFSLTAIT AVLAVSAVPT PSNNKDGSTI SELPENWDQT KDDNRSLFLN KSDKNDLEPY
     PLALSEEGNQ DGYDQTVDQR FDSPQSNGEL DNLIMRPELY GEPPAMEGLA SAFDLQRRKR
     GSGTKVGGAG AATKVVTKSG SGKKNLKPED QAALSPIDLM TQHEAQRRKR GSGTKVGGAA
     ASAKTATKNS GGNKKNFRPI SERRKRDSGL SAADVRALLN LWEAQERRKQ EYANQFAADR
     YYGRVNPDEE QPEVDENGDL WYNEPVVIGP HDRDYPHHSY FSEQNRMALA RGYPDLYQVG
     PNELAQRYEE ARRKRQYANK MKRFMVAKKR SDNMMHQNNY RPRDDLYTLA ELLRSAPRVQ
     EQDIPVYRRL IL