ID   NEURM_HIRME             Reviewed;          82 AA.
AC   A8V0B3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Neuromacin;
DE   Flags: Precursor;
OS   Hirudo medicinalis (Medicinal leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Hirudo.
OX   NCBI_TaxID=6421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18606660; DOI=10.4049/jimmunol.181.2.1083;
RA   Schikorski D., Cuvillier-Hot V., Leippe M., Boidin-Wichlacz C.,
RA   Slomianny C., Macagno E., Salzet M., Tasiemski A.;
RT   "Microbial challenge promotes the regenerative process of the injured
RT   central nervous system of the medicinal leech by inducing the synthesis of
RT   antimicrobial peptides in neurons and microglia.";
RL   J. Immunol. 181:1083-1095(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the macin family. {ECO:0000305}.
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DR   EMBL; EU156754; ABW97519.1; -; mRNA.
DR   AlphaFoldDB; A8V0B3; -.
DR   SMR; A8V0B3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   Gene3D; 3.30.30.100; -; 1.
DR   InterPro; IPR029230; Macin.
DR   InterPro; IPR038456; Macin_sf.
DR   Pfam; PF14865; Macin; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..82
FT                   /note="Neuromacin"
FT                   /id="PRO_0000342203"
FT   DISULFID        25..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9315 MW;  4A059EB30224A26C CRC64;
     MALLNKLLCF ALVFMIFGEF VTPDCYEDWS RCTPGTSFLT GILWKDCHSR CKELGHRGGR
     CVDSPSKHCP GVLKNNKQCH CY