ID   NEUR_DROVI              Reviewed;         747 AA.
AC   Q24746;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Protein neuralized;
GN   Name=neur; Synonyms=neu;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8001814; DOI=10.1139/g94-119;
RA   Zhou L., Boulianne G.L.;
RT   "Comparison of the neuralized genes of Drosophila virilis and D.
RT   melanogaster.";
RL   Genome 37:840-847(1994).
CC   -!- FUNCTION: Involved in neurogenesis. Interacts with other neurogenic
CC       proteins in the specification of the neuroblast versus epidermoblast
CC       cell fate.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; U12593; AAB60619.1; -; Genomic_DNA.
DR   EMBL; U12591; AAB60619.1; JOINED; Genomic_DNA.
DR   EMBL; U12592; AAB60619.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q24746; -.
DR   SMR; Q24746; -.
DR   STRING; 7244.FBpp0225292; -.
DR   PRIDE; Q24746; -.
DR   eggNOG; KOG4172; Eukaryota.
DR   eggNOG; KOG4625; Eukaryota.
DR   GO; GO:0005768; C:endosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:EnsemblMetazoa.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblMetazoa.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0008356; P:asymmetric cell division; IEA:EnsemblMetazoa.
DR   GO; GO:0048749; P:compound eye development; IEA:EnsemblMetazoa.
DR   GO; GO:0030718; P:germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0035204; P:negative regulation of lamellocyte differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0007400; P:neuroblast fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0007422; P:peripheral nervous system development; ISS:UniProtKB.
DR   GO; GO:0045807; P:positive regulation of endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0008104; P:protein localization; IEA:EnsemblMetazoa.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblMetazoa.
DR   GO; GO:0045314; P:regulation of compound eye photoreceptor development; IEA:EnsemblMetazoa.
DR   GO; GO:0007423; P:sensory organ development; ISS:UniProtKB.
DR   GO; GO:0016360; P:sensory organ precursor cell fate determination; ISS:UniProtKB.
DR   Gene3D; 2.60.120.920; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR037962; Neuralized.
DR   InterPro; IPR006573; NHR_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12429; PTHR12429; 1.
DR   Pfam; PF07177; Neuralized; 2.
DR   SMART; SM00588; NEUZ; 2.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51065; NHR; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..747
FT                   /note="Protein neuralized"
FT                   /id="PRO_0000055976"
FT   DOMAIN          97..251
FT                   /note="NHR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   DOMAIN          359..514
FT                   /note="NHR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00400"
FT   ZN_FING         694..735
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          280..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..306
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  81983 MW;  C8E72569D6FDCA11 CRC64;
     MGLSDIPANY MQQTGHNLQQ QQLHHHHHHN HNHNHNAAAA AAAAAHVLAM ENSELLMSPK
     DKMSSKKKMH LLKKIKKRFG LVRRSPSSCP GPNNLPPLQF HTVHGDNIRI SRDGTLARRF
     ESFCRAITFS ARPVRINERI CVKFAEISNN WNGGIRFGFT SNDPASLEGA LPKYACPDLT
     NRPGFWAKAL HEQYCEKDNI LYYYVNNAGD VIYGINNEEK GVILSGIDTR GLLWTVIDIY
     GNCTGIEFLD ARIYMYQQQQ QQQQQQQQQL QQQQLPQQQL PQQQQQLPQQ QLTAHHPLQQ
     SRRSLPGGTG VVVDHELERH VMPSLQSLHL AGTAAGIIEH DLANGLPPLR YNANGRLIPV
     PFHITKGRNV RLSHDRFVAS RTESDFCQGY VFTARPIRIG EKLIVQVLKT EQMYVGALAL
     GLTSCNPALL QPNDLPNDSD FLLDRPEYWV VSKDIAAAPQ RGDEIAFFVA PNGEVSISKN
     NGPAVVVMHV DQSLQLWAFL DVYGSTQSLR MFRQQLPNMV AYPSQPQINA AAAAAAAAAS
     TTAASSRMLP MAESLNSLNA GQMLRSKMQL NVTQSSSTLA STAGNGSRMI SMPSNGDILQ
     IQPNGGGTVL VVNLPPRSSS HDLNGQLAGR QAASAATVTS SGILAGACSS GTLISTTSSQ
     QYIEPVAQST STLNGTKWKD SLSDQQSTDS SAECTICYEN PIDSVLYMCG HMCMCYDCAI
     EQWRGVGGGQ CPLCRAVIRD VIRTYTT