ID   NEUT_CAVPO              Reviewed;          13 AA.
AC   P32560;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Neurotensin;
DE            Short=NT;
GN   Name=NTS;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Small intestine;
RX   PubMed=3087775; DOI=10.1016/0014-5793(86)80684-6;
RA   Shaw C., Thim L., Conlon J.M.;
RT   "[Ser7]neurotensin: isolation from guinea pig intestine.";
RL   FEBS Lett. 202:187-192(1986).
CC   -!- FUNCTION: Smooth muscle-contracting peptide.
CC   -!- SUBUNIT: Interacts with NTSR1. Interacts with SORT1. Interacts with
CC       SORL1. {ECO:0000250|UniProtKB:P30990}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: [Neurotensin]: Neurotensin is cleaved and degraded by Angiotensin-
CC       converting enzyme (ACE) and neprilysin (MME).
CC       {ECO:0000250|UniProtKB:P30990}.
CC   -!- SIMILARITY: Belongs to the neurotensin family. {ECO:0000305}.
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DR   PIR; A53608; A53608.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Vasoactive.
FT   PEPTIDE         1..13
FT                   /note="Neurotensin"
FT                   /id="PRO_0000044067"
FT   SITE            10..11
FT                   /note="Cleavage; by MME"
FT                   /evidence="ECO:0000250|UniProtKB:P30990"
FT   SITE            11..12
FT                   /note="Cleavage; by ACE and MME"
FT                   /evidence="ECO:0000250|UniProtKB:P30990"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3087775"
SQ   SEQUENCE   13 AA;  1680 MW;  4C8314644C4115B3 CRC64;
     QLYENKSRRP YIL