ID   NEUT_TRIVU              Reviewed;          13 AA.
AC   P31745;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 2.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Neurotensin;
DE            Short=NT;
GN   Name=NTS;
OS   Trichosurus vulpecula (Brush-tailed possum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Phalangeridae; Trichosurus.
OX   NCBI_TaxID=9337;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Small intestine;
RX   PubMed=1924896; DOI=10.1016/0167-0115(91)90253-d;
RA   Shaw C., Murphy R., Thim L., Furness J.B., Buchanan K.D.;
RT   "Marsupial possum neurotensin: a unique mammalian regulatory peptide
RT   exhibiting structural homology to the avian analogue.";
RL   Regul. Pept. 35:49-57(1991).
CC   -!- FUNCTION: Smooth muscle-contracting peptide.
CC   -!- SUBUNIT: Interacts with NTSR1. Interacts with SORT1. Interacts with
CC       SORL1. {ECO:0000250|UniProtKB:P30990}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: [Neurotensin]: Neurotensin is cleaved and degraded by Angiotensin-
CC       converting enzyme (ACE) and neprilysin (MME).
CC       {ECO:0000250|UniProtKB:P30990}.
CC   -!- SIMILARITY: Belongs to the neurotensin family. {ECO:0000305}.
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DR   PIR; A60064; UNOPBT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Pyrrolidone carboxylic acid; Secreted;
KW   Vasoactive.
FT   PEPTIDE         1..13
FT                   /note="Neurotensin"
FT                   /id="PRO_0000044068"
FT   SITE            10..11
FT                   /note="Cleavage; by MME"
FT                   /evidence="ECO:0000250|UniProtKB:P30990"
FT   SITE            11..12
FT                   /note="Cleavage; by ACE and MME"
FT                   /evidence="ECO:0000250|UniProtKB:P30990"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1924896"
SQ   SEQUENCE   13 AA;  1610 MW;  4C949E74EC410DD3 CRC64;
     QLHVNKARRV YIL