ID   NEUV_BUFJA              Reviewed;         159 AA.
AC   P08163;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Vasotocin-neurophysin VT;
DE            Short=VT;
DE   Contains:
DE     RecName: Full=Hydrin-2;
DE     AltName: Full=Hydrin II;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE   Contains:
DE     RecName: Full=Neurophysin VT;
DE   Contains:
DE     RecName: Full=Glycoprotein;
DE   Flags: Precursor; Fragment;
OS   Bufo japonicus (Japanese toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo.
OX   NCBI_TaxID=8387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3033676; DOI=10.1073/pnas.84.9.3043;
RA   Nojiri H., Ishida I., Miyashita E., Sato M., Urano A., Deguchi T.;
RT   "Cloning and sequence analysis of cDNAs for neurohypophysial hormones
RT   vasotocin and mesotocin for the hypothalamus of toad, Bufo japonicus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:3043-3046(1987).
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M16233; AAA48556.1; -; mRNA.
DR   PIR; B29879; B29879.
DR   AlphaFoldDB; P08163; -.
DR   SMR; P08163; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          <1..17
FT   PEPTIDE         18..27
FT                   /note="Hydrin-2"
FT                   /id="PRO_0000020534"
FT   PEPTIDE         18..26
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020535"
FT   CHAIN           30..122
FT                   /note="Neurophysin VT"
FT                   /id="PRO_0000020536"
FT   PEPTIDE         124..159
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000020537"
FT   MOD_RES         26
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        18..23
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        39..83
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        50..73
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        57..63
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        90..102
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        96..114
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        103..108
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   NON_TER         1
SQ   SEQUENCE   159 AA;  17072 MW;  536EC10283BC53E4 CRC64;
     TAPVPACFLC LLALSSACYI QNCPRGGKRS YPDTAVRQCI PCGPGNRGNC FGPNICCGED
     LGCYVGTPET LRCVEETYLP SPCEAGGKPC SSGGRCAAPG VCCSDDTCVV DSSCLDEDSE
     RRRVTPEQNM TQMDGSASDL LLRLMHMANR QQQSKHQFY