ID   NEUV_CHICK              Reviewed;         161 AA.
AC   P24787;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Vasotocin-neurophysin VT;
DE   Contains:
DE     RecName: Full=Vasotocin;
DE              Short=VT;
DE   Contains:
DE     RecName: Full=Neurophysin VT;
DE   Flags: Precursor;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Hypothalamus;
RA   Hunt N., Kluever D., Ivell R.;
RL   Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Vasotocin is an antidiuretic hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; X55130; CAA38923.1; -; mRNA.
DR   PIR; S14480; S14480.
DR   RefSeq; NP_990516.1; NM_205185.2.
DR   AlphaFoldDB; P24787; -.
DR   SMR; P24787; -.
DR   STRING; 9031.ENSGALP00000022811; -.
DR   PaxDb; P24787; -.
DR   Ensembl; ENSGALT00000022851; ENSGALP00000022811; ENSGALG00000014117.
DR   GeneID; 396101; -.
DR   KEGG; gga:396101; -.
DR   CTD; 551; -.
DR   VEuPathDB; HostDB:geneid_396101; -.
DR   eggNOG; ENOG502S21K; Eukaryota.
DR   GeneTree; ENSGT00390000004511; -.
DR   HOGENOM; CLU_125770_0_0_1; -.
DR   InParanoid; P24787; -.
DR   OMA; CSADTCA; -.
DR   OrthoDB; 1548839at2759; -.
DR   PhylomeDB; P24787; -.
DR   TreeFam; TF333018; -.
DR   Reactome; R-GGA-388479; Vasopressin-like receptors.
DR   Reactome; R-GGA-416476; G alpha (q) signalling events.
DR   Reactome; R-GGA-879518; Transport of organic anions.
DR   PRO; PR:P24787; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000014117; Expressed in brain and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0031894; F:V1A vasopressin receptor binding; IBA:GO_Central.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT   PEPTIDE         20..28
FT                   /note="Vasotocin"
FT                   /id="PRO_0000020532"
FT   CHAIN           32..161
FT                   /note="Neurophysin VT"
FT                   /id="PRO_0000020533"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..25
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        41..85
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        52..75
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        59..65
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        92..104
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        98..116
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        105..110
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   161 AA;  16693 MW;  2802FBBED5E52277 CRC64;
     MAEPSLPLSF LCLLALSSAC YIQNCPRGGK RALGDTALRQ CLPCGPGNRG RCFGPGICCG
     AELGCYLGTA ETRRCAEEDY MPSPCQAGGQ PCGSDGRCAA NGVCCSADTC AMDAVCLEEG
     SEQAEEAAEK NLTVLDGAAG DLLLRLMHLA NRQQQGKQPG L