NEUV_TAKRU
ID NEUV_TAKRU Reviewed; 153 AA.
AC O42499;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Vasotocin-neurophysin VT 1;
DE Contains:
DE RecName: Full=Vasotocin;
DE Short=VT;
DE Contains:
DE RecName: Full=Neurophysin VT 1;
DE Flags: Precursor;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8714027;
RA Venkatesh B., Brenner S.;
RT "Structure and organization of the isotocin and vasotocin genes from
RT teleosts.";
RL Adv. Exp. Med. Biol. 395:629-638(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9356472; DOI=10.1073/pnas.94.23.12462;
RA Venkatesh B., Si-Hoe S.L., Murphy D., Brenner S.;
RT "Transgenic rats reveal functional conservation of regulatory controls
RT between the Fugu isotocin and rat oxytocin genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:12462-12466(1997).
CC -!- FUNCTION: Vasotocin is probably an antidiuretic hormone.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Seven disulfide bonds are present in neurophysin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR EMBL; U90880; AAC60293.1; -; Genomic_DNA.
DR AlphaFoldDB; O42499; -.
DR SMR; O42499; -.
DR STRING; 31033.ENSTRUP00000039403; -.
DR eggNOG; ENOG502S21K; Eukaryota.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR Gene3D; 2.60.9.10; -; 1.
DR InterPro; IPR000981; Neurhyp_horm.
DR InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR PANTHER; PTHR11681; PTHR11681; 1.
DR Pfam; PF00220; Hormone_4; 1.
DR Pfam; PF00184; Hormone_5; 1.
DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR PRINTS; PR00831; NEUROPHYSIN.
DR SMART; SM00003; NH; 1.
DR SUPFAM; SSF49606; SSF49606; 1.
DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT PEPTIDE 20..28
FT /note="Vasotocin"
FT /id="PRO_0000020556"
FT CHAIN 32..153
FT /note="Neurophysin VT 1"
FT /id="PRO_0000020557"
FT MOD_RES 28
FT /note="Glycine amide"
FT /evidence="ECO:0000250"
FT DISULFID 20..25
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 41..85
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 44..58
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 52..75
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 59..65
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 92..105
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 99..117
FT /evidence="ECO:0000250|UniProtKB:P01175"
FT DISULFID 106..111
FT /evidence="ECO:0000250|UniProtKB:P01175"
SQ SEQUENCE 153 AA; 15890 MW; 181BC50F78890CCB CRC64;
MPQCALLLSL LGLLALSSAC YIQNCPRGGK RALPETGIRQ CMSCGPRDRG RCFGPNICCG
EALGCLMGSP ETARCAGENY LLTPCQAGGR PCGSEGGRCA VSGLCCNSES CAVDSDCLGE
TESLEPGDSS ADSSPTELLL RLLHMSSRGQ SEY
