NEXMI_RAT
ID NEXMI_RAT Reviewed; 1517 AA.
AC D3ZGX1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Neurite extension and migration factor {ECO:0000250|UniProtKB:Q5QGS0};
DE AltName: Full=KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog {ECO:0000303|PubMed:27822498};
DE Short=KIDLIA {ECO:0000303|PubMed:27822498};
DE AltName: Full=XLMR protein related to neurite extension {ECO:0000303|PubMed:24071057};
DE Short=Xpn {ECO:0000303|PubMed:24071057};
GN Name=Nexmif {ECO:0000250|UniProtKB:Q5QGS0};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP FUNCTION IN NEURONAL DEVELOPMENT.
RX PubMed=23615299; DOI=10.1093/hmg/ddt187;
RA Van Maldergem L., Hou Q., Kalscheuer V.M., Rio M., Doco-Fenzy M.,
RA Medeira A., de Brouwer A.P., Cabrol C., Haas S.A., Cacciagli P.,
RA Moutton S., Landais E., Motte J., Colleaux L., Bonnet C., Villard L.,
RA Dupont J., Man H.Y.;
RT "Loss of function of KIAA2022 causes mild to severe intellectual disability
RT with an autism spectrum disorder and impairs neurite outgrowth.";
RL Hum. Mol. Genet. 22:3306-3314(2013).
RN [3]
RP FUNCTION.
RX PubMed=22531377; DOI=10.1016/j.neuroscience.2012.04.030;
RA Ishikawa T., Miyata S., Koyama Y., Yoshikawa K., Hattori T., Kumamoto N.,
RA Shingaki K., Katayama T., Tohyama M.;
RT "Transient expression of Xpn, an XLMR protein related to neurite extension,
RT during brain development and participation in neurite outgrowth.";
RL Neuroscience 214:181-191(2012).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24071057; DOI=10.1016/j.neuint.2013.09.011;
RA Magome T., Hattori T., Taniguchi M., Ishikawa T., Miyata S., Yamada K.,
RA Takamura H., Matsuzaki S., Ito A., Tohyama M., Katayama T.;
RT "XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-
RT cell and cell-matrix adhesion and migration.";
RL Neurochem. Int. 63:561-569(2013).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=27822498; DOI=10.1523/eneuro.0238-16.2016;
RA Gilbert J., Man H.Y.;
RT "The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth
RT via N-cadherin and delta-catenin signaling.";
RL ENeuro 3:0-0(2016).
CC -!- FUNCTION: Involved in neurite outgrowth by regulating cell-cell
CC adhesion via the N-cadherin signaling pathway (PubMed:23615299,
CC PubMed:22531377, PubMed:24071057, PubMed:27822498). May act by
CC regulating expression of protein-coding genes, such as N-cadherins and
CC integrin beta-1 (ITGB1) (PubMed:24071057, PubMed:27822498).
CC {ECO:0000269|PubMed:22531377, ECO:0000269|PubMed:23615299,
CC ECO:0000269|PubMed:24071057, ECO:0000269|PubMed:27822498}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24071057,
CC ECO:0000269|PubMed:27822498}. Cytoplasm {ECO:0000250|UniProtKB:Q5DTT1}.
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DR EMBL; AABR06105592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001300744.1; NM_001313815.1.
DR RefSeq; XP_008771572.1; XM_008773350.2.
DR RefSeq; XP_017457455.1; XM_017601966.1.
DR AlphaFoldDB; D3ZGX1; -.
DR STRING; 10116.ENSRNOP00000036176; -.
DR iPTMnet; D3ZGX1; -.
DR PhosphoSitePlus; D3ZGX1; -.
DR PaxDb; D3ZGX1; -.
DR PeptideAtlas; D3ZGX1; -.
DR Ensembl; ENSRNOT00000035653; ENSRNOP00000036176; ENSRNOG00000021589.
DR GeneID; 302396; -.
DR KEGG; rno:302396; -.
DR UCSC; RGD:1561931; rat.
DR CTD; 340533; -.
DR RGD; 1561931; Nexmif.
DR eggNOG; ENOG502QUMY; Eukaryota.
DR GeneTree; ENSGT00940000159746; -.
DR HOGENOM; CLU_250004_0_0_1; -.
DR InParanoid; D3ZGX1; -.
DR OMA; MMEPGTV; -.
DR OrthoDB; 59480at2759; -.
DR PhylomeDB; D3ZGX1; -.
DR TreeFam; TF332248; -.
DR PRO; PR:D3ZGX1; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000021589; Expressed in brain and 8 other tissues.
DR Genevisible; D3ZGX1; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IMP:RGD.
DR GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; IMP:RGD.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IMP:RGD.
DR GO; GO:2001223; P:negative regulation of neuron migration; IMP:RGD.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR InterPro; IPR032757; DUF4683.
DR InterPro; IPR042794; Nexmif.
DR PANTHER; PTHR46946; PTHR46946; 1.
DR Pfam; PF15735; DUF4683; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1517
FT /note="Neurite extension and migration factor"
FT /id="PRO_0000426094"
FT REGION 381..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1517 AA; 166662 MW; 07F8287E212F4119 CRC64;
MDNQQDKVIA ASANGENNLI NGVKENDSEE QDVAMKSFAA LEASTPIQPI PVVQKESPMF
PRGLLPLPSK KPCMQSPPSP LGLIEAPDHS ATGASVNAIS LTSGVAKGLN TWSLPNECEK
APFAIMEPAG ISALNGDCLM QPSRTCLGCF MESKEAVDPE PGISLKVGDL NRDYETCAVS
DIGIQCINAG ENLKYGEQLL SDQLLGFPLH KSRAGDRRES EKPDIDLEDP TQKSYYEALL
LDKCNTEEAL LANSNQDWGY FETFISESKI ELLDLCSKNE LSVNLFSEED VENYMFDDDE
STLGSDVCSL KIRYESFQDN VRDKTTLLMQ EDAQFNFFPS VFTTCPKRES KSGVLKQSSD
LSQFKVPDVS IIWGDEDKNL DKKKGKEEVH EDKSIEKKDE KDNGEKPALN NKPCSGLEVE
QFKNLKPDHL TNSLETSGNF SDDSSFIEVS YDAMGEIKDC SRYMARDTNS GSSSSQQNYG
LRAKRKVRYS EDYLYDVDSL EGEKVNERKE WPPGGSKEED DDEWCPKKRR KVTRKEPPVI
IKYIIINRFK GEKNMLVKLG KVDASETTVN LSESQLSKYA KLSPLKGFWQ KKKKQKNGNT
DSVKTPFCQK QSFEPGSFEV SFLPPARKRK SKLGNRHRIQ RIQSMEASAS SKQVSFGSDQ
KQASNRKEEG GLKGTPKSAL LAAPSSANGS HLRGLIGPDS AKVKAQDTEF KGPERKVLNK
IKFKSEARLK SKKIKTGQEN KPVVQMSPVS EDPSSKANLK NEVTPGTSNS SHMSEFHETK
VVKNSTFLPT TCSSEMPLSS ANVATNIPVI PGGYLQTLLD ASDLSNNTSI SYFTNHSAEQ
NEASLSQTEK AFAPLQSAQD CVLSSSSDSQ LQQSSQNFKM EASNYGSLWP DKDTSGSQEF
MTEVSGEIAT SQSSEFEATQ VVSMENNLTA ITYSPVCLNS GGSGCNKVLY ASVQDSHLAP
DDSYQLCHFN NGEICFPFQQ GPISTEDDGQ LFSFDSMTPL SVSSSSYCPL SLKSCEKDGD
DDINDDFLAH CSPKLVIQQS IDEIAPLKES TDLLDISNFT PDKFRHSSLS EMSPPDTPSL
SPQSTRCESI KTLGTMKGFQ EGVPGSLSSM EKIKWDCSTL SQQVQADDGF TLNNHQFQFH
MFNDEDSVGL LQKNPCLSTF DEPAGQISAN NKVSKSRKKT SPGKSGAVSQ SSSQKNTRKK
SPKASNKGVE KPPSKTSRQV PKSAKKGKYV AAVNGEKMQI GIGHSGGQPN STSSNGKTLT
ECIQHGGPVA PMKIPSQKGL SGDWALGKES RPGWNDMSVV TNTNNLLDDD QREFQEPSYI
LSNIASGMAD VQRFMMASME PLWEPMEHQG ESNTFYSPDS NSLKLKTLKI LAGTPQESKK
KINNGSSGAT KNHRSIKAVS KSSGKAAVGD PGHADVSGSS EDSRSAFFDK KYSNMNTLGN
NGPTHKKLYR HKSSSKTLRD EKYKGKRVER EQIHKDEAGT TCFEKLRGSS YNLLKAETAF
GVLPVFEEET HIFQKDI
