ID   NF1_CHICK               Reviewed;         270 AA.
AC   P35608;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Neurofibromin;
DE   AltName: Full=Neurofibromatosis-related protein NF-1;
DE   Flags: Fragment;
GN   Name=NF1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8507305; DOI=10.1007/bf03160119;
RA   Schafer G.L., Ciment G., Stocker K.M., Baizer L.;
RT   "Analysis of the sequence and embryonic expression of chicken neurofibromin
RT   mRNA.";
RL   Mol. Chem. Neuropathol. 18:267-278(1993).
CC   -!- FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater
CC       affinity for Ras GAP, but lower specific activity. May be a regulator
CC       of Ras activity.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}.
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DR   EMBL; S62087; AAB27069.1; -; mRNA.
DR   AlphaFoldDB; P35608; -.
DR   SMR; P35608; -.
DR   STRING; 9031.ENSGALP00000009067; -.
DR   PaxDb; P35608; -.
DR   VEuPathDB; HostDB:geneid_396085; -.
DR   eggNOG; KOG1826; Eukaryota.
DR   InParanoid; P35608; -.
DR   OrthoDB; 9686at2759; -.
DR   PhylomeDB; P35608; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0048147; P:negative regulation of fibroblast proliferation; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   GTPase activation; Nucleus; Reference proteome.
FT   CHAIN           <1..>270
FT                   /note="Neurofibromin"
FT                   /id="PRO_0000056668"
FT   NON_TER         1
FT   NON_TER         270
SQ   SEQUENCE   270 AA;  30754 MW;  A376822397BD32C6 CRC64;
     RARVIHSLCT CSQLHFSEET KQVLRLSLTE FSLPKFYLLF GISKVKSAAV IAFRSSYRDR
     SFSPGSYERE TFALTSLETV TEALLEIMEA CMRDIPTCKW LDQWTELAQK FAFQYNPSLQ
     PRALVVFGCI SKRVSHGQIK QIIRILSKGL ESCLKGPDNY NSQVLIEATV IALTKLQPLL
     NKDSPMHKAL FWVAMAVLEL DEVNLYSAGT ALLEQNLHTL DSLRVFNDKS PEEVFMEIRR
     PLEWHCKQMD HFVGLNFNSN FNFALVGPGP