NF1_MOUSE
ID NF1_MOUSE Reviewed; 2841 AA.
AC Q04690; Q61956; Q61957;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Neurofibromin;
DE AltName: Full=Neurofibromatosis-related protein NF-1;
GN Name=Nf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=8353485; DOI=10.1093/hmg/2.6.645;
RA Bernards A., Snijders A.J., Hannigan G.E., Murthy A.E., Gusella J.F.;
RT "Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of
RT conservation of both coding and non-coding mRNA segments.";
RL Hum. Mol. Genet. 2:645-650(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1178-1555, ALTERNATIVE SPLICING (ISOFORMS I;
RP II; III AND IV), AND TISSUE SPECIFICITY.
RX PubMed=7958951; DOI=10.1016/0378-1119(94)90695-5;
RA Mantani A., Makasugi S., Yokota Y., Abe K., Ushio Y., Yamamura K.;
RT "A novel isoform of the neurofibromatosis type-1 mRNA and a switch of
RT isoforms during murine cell differentiation and proliferation.";
RL Gene 148:245-251(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 1950-2568.
RX PubMed=2169593; DOI=10.1038/347291a0;
RA Buchberg A.M., Cleveland L.S., Jenkins N.A., Copeland N.G.;
RT "Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and
RT IRA-2 negative regulators of the RAS cyclic AMP pathway.";
RL Nature 347:291-294(1990).
RN [4]
RP PROTEIN SEQUENCE OF 1973-1979, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-866; SER-878; SER-2469;
RP THR-2516; SER-2517; SER-2525 AND SER-2599, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater
CC affinity for Ras GAP, but lower specific activity. May be a regulator
CC of Ras activity.
CC -!- SUBUNIT: Interacts with HTR6 (By similarity).
CC {ECO:0000250|UniProtKB:P21359}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=II {ECO:0000303|PubMed:7958951};
CC IsoId=Q04690-1; Sequence=Displayed;
CC Name=I {ECO:0000303|PubMed:7958951};
CC IsoId=Q04690-2; Sequence=VSP_001633;
CC Name=III {ECO:0000303|PubMed:7958951};
CC IsoId=Q04690-3; Sequence=VSP_001634, VSP_001635;
CC Name=IV {ECO:0000303|Ref.4};
CC IsoId=Q04690-4; Sequence=VSP_001633, VSP_001634, VSP_001635;
CC -!- TISSUE SPECIFICITY: [Isoform I]: Expressed predominantly in brain,
CC spinal cord and testis. {ECO:0000269|PubMed:7958951}.
CC -!- TISSUE SPECIFICITY: [Isoform II]: Expressed predominantly in adrenal
CC gland, kidney, ovary and lung. {ECO:0000269|PubMed:7958951}.
CC -!- TISSUE SPECIFICITY: [Isoform III]: Widely and more weakly expressed.
CC Predominantly expressed in adrenal gland. {ECO:0000269|PubMed:7958951}.
CC -!- TISSUE SPECIFICITY: [Isoform IV]: Widely and more weakly expressed.
CC Expressed mainly in testis. {ECO:0000269|PubMed:7958951}.
CC -!- DOMAIN: Binds phospholipids via a region that includes the CRAL-TRIO
CC domain. Binds primarily glycerophospholipids with monounsaturated C18:1
CC and/or C16:1 fatty acid moieties and a phosphatidylethanolamine or
CC phosphatidylcholine headgroup. Has lesser affinity for lipids
CC containing phosphatidylserine and phosphatidylinositol (By similarity).
CC {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L10369; AAA39806.1; -; Genomic_DNA.
DR EMBL; L10367; AAA39806.1; JOINED; Genomic_DNA.
DR EMBL; L10368; AAA39806.1; JOINED; Genomic_DNA.
DR EMBL; L10370; AAA68132.1; -; mRNA.
DR EMBL; X54924; CAA38690.1; -; mRNA.
DR EMBL; D30730; BAA06395.1; -; mRNA.
DR EMBL; D30731; BAA06396.1; -; mRNA.
DR CCDS; CCDS25119.1; -. [Q04690-1]
DR PIR; I53855; I53855.
DR PIR; I54352; I54352.
DR PIR; I67934; I67934.
DR PIR; I68623; I68623.
DR RefSeq; NP_035027.1; NM_010897.2. [Q04690-1]
DR RefSeq; XP_006532504.1; XM_006532441.3. [Q04690-2]
DR SMR; Q04690; -.
DR BioGRID; 201736; 20.
DR IntAct; Q04690; 11.
DR MINT; Q04690; -.
DR STRING; 10090.ENSMUSP00000071289; -.
DR ChEMBL; CHEMBL2176807; -.
DR iPTMnet; Q04690; -.
DR PhosphoSitePlus; Q04690; -.
DR SwissPalm; Q04690; -.
DR EPD; Q04690; -.
DR jPOST; Q04690; -.
DR MaxQB; Q04690; -.
DR PaxDb; Q04690; -.
DR PeptideAtlas; Q04690; -.
DR PRIDE; Q04690; -.
DR ProteomicsDB; 252826; -. [Q04690-1]
DR ProteomicsDB; 252827; -. [Q04690-2]
DR ProteomicsDB; 252828; -. [Q04690-3]
DR ProteomicsDB; 252829; -. [Q04690-4]
DR Antibodypedia; 3471; 487 antibodies from 39 providers.
DR DNASU; 18015; -.
DR Ensembl; ENSMUST00000071325; ENSMUSP00000071289; ENSMUSG00000020716. [Q04690-1]
DR Ensembl; ENSMUST00000108251; ENSMUSP00000103886; ENSMUSG00000020716. [Q04690-2]
DR GeneID; 18015; -.
DR KEGG; mmu:18015; -.
DR UCSC; uc007kkl.1; mouse. [Q04690-1]
DR CTD; 4763; -.
DR MGI; MGI:97306; Nf1.
DR VEuPathDB; HostDB:ENSMUSG00000020716; -.
DR eggNOG; KOG1826; Eukaryota.
DR GeneTree; ENSGT00550000074797; -.
DR HOGENOM; CLU_000249_0_0_1; -.
DR InParanoid; Q04690; -.
DR OMA; WSIDMEA; -.
DR OrthoDB; 9686at2759; -.
DR PhylomeDB; Q04690; -.
DR TreeFam; TF300302; -.
DR Reactome; R-MMU-5658442; Regulation of RAS by GAPs.
DR BioGRID-ORCS; 18015; 17 hits in 82 CRISPR screens.
DR ChiTaRS; Nf1; mouse.
DR PRO; PR:Q04690; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q04690; protein.
DR Bgee; ENSMUSG00000020716; Expressed in spermatocyte and 178 other tissues.
DR ExpressionAtlas; Q04690; baseline and differential.
DR Genevisible; Q04690; MM.
DR GO; GO:0030424; C:axon; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0014069; C:postsynaptic density; ISO:MGI.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0005096; F:GTPase activator activity; IMP:MGI.
DR GO; GO:0008017; F:microtubule binding; ISO:MGI.
DR GO; GO:0031210; F:phosphatidylcholine binding; ISS:UniProtKB.
DR GO; GO:0008429; F:phosphatidylethanolamine binding; ISS:UniProtKB.
DR GO; GO:0045545; F:syndecan binding; ISO:MGI.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
DR GO; GO:0030325; P:adrenal gland development; IMP:MGI.
DR GO; GO:0021764; P:amygdala development; IGI:MGI.
DR GO; GO:0001525; P:angiogenesis; IGI:MGI.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0048844; P:artery morphogenesis; IMP:MGI.
DR GO; GO:0048708; P:astrocyte differentiation; IMP:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.
DR GO; GO:0007154; P:cell communication; IMP:MGI.
DR GO; GO:0016477; P:cell migration; IMP:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0034605; P:cellular response to heat; IDA:MGI.
DR GO; GO:0021987; P:cerebral cortex development; IMP:MGI.
DR GO; GO:0050890; P:cognition; ISO:MGI.
DR GO; GO:0030199; P:collagen fibril organization; IMP:MGI.
DR GO; GO:0001935; P:endothelial cell proliferation; IMP:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IMP:MGI.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IMP:MGI.
DR GO; GO:0048144; P:fibroblast proliferation; IMP:MGI.
DR GO; GO:0021897; P:forebrain astrocyte development; IMP:MGI.
DR GO; GO:0048853; P:forebrain morphogenesis; IMP:MGI.
DR GO; GO:0061534; P:gamma-aminobutyric acid secretion, neurotransmission; IGI:MGI.
DR GO; GO:0014009; P:glial cell proliferation; IMP:MGI.
DR GO; GO:0061535; P:glutamate secretion, neurotransmission; IGI:MGI.
DR GO; GO:0048820; P:hair follicle maturation; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0071887; P:leukocyte apoptotic process; IMP:MGI.
DR GO; GO:0001889; P:liver development; IMP:MGI.
DR GO; GO:0000165; P:MAPK cascade; IMP:MGI.
DR GO; GO:0033024; P:mast cell apoptotic process; IGI:MGI.
DR GO; GO:0070662; P:mast cell proliferation; IGI:MGI.
DR GO; GO:0001656; P:metanephros development; IMP:MGI.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
DR GO; GO:0033028; P:myeloid cell apoptotic process; IMP:MGI.
DR GO; GO:0097529; P:myeloid leukocyte migration; IGI:MGI.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IGI:MGI.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IMP:MGI.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IGI:MGI.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:MGI.
DR GO; GO:0002686; P:negative regulation of leukocyte migration; IGI:MGI.
DR GO; GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.
DR GO; GO:0070667; P:negative regulation of mast cell proliferation; IGI:MGI.
DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI.
DR GO; GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:MGI.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IGI:MGI.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IMP:MGI.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IMP:MGI.
DR GO; GO:0035021; P:negative regulation of Rac protein signal transduction; IGI:MGI.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:MGI.
DR GO; GO:1900148; P:negative regulation of Schwann cell migration; IMP:MGI.
DR GO; GO:0010626; P:negative regulation of Schwann cell proliferation; IMP:MGI.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IGI:MGI.
DR GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IGI:MGI.
DR GO; GO:0021915; P:neural tube development; IGI:MGI.
DR GO; GO:0007405; P:neuroblast proliferation; IMP:MGI.
DR GO; GO:0051402; P:neuron apoptotic process; IMP:MGI.
DR GO; GO:0007269; P:neurotransmitter secretion; IMP:MGI.
DR GO; GO:0098597; P:observational learning; IGI:MGI.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
DR GO; GO:0030316; P:osteoclast differentiation; IGI:MGI.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IMP:MGI.
DR GO; GO:0043473; P:pigmentation; IMP:MGI.
DR GO; GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IMP:MGI.
DR GO; GO:2000108; P:positive regulation of leukocyte apoptotic process; IMP:MGI.
DR GO; GO:0033027; P:positive regulation of mast cell apoptotic process; IGI:MGI.
DR GO; GO:0033034; P:positive regulation of myeloid cell apoptotic process; IMP:MGI.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IGI:MGI.
DR GO; GO:0006606; P:protein import into nucleus; IMP:MGI.
DR GO; GO:0016601; P:Rac protein signal transduction; IGI:MGI.
DR GO; GO:0007265; P:Ras protein signal transduction; IMP:MGI.
DR GO; GO:0045765; P:regulation of angiogenesis; IMP:MGI.
DR GO; GO:0043535; P:regulation of blood vessel endothelial cell migration; ISO:MGI.
DR GO; GO:0045124; P:regulation of bone resorption; IMP:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IGI:MGI.
DR GO; GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0045685; P:regulation of glial cell differentiation; IMP:MGI.
DR GO; GO:0043087; P:regulation of GTPase activity; ISO:MGI.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
DR GO; GO:1900271; P:regulation of long-term synaptic potentiation; IGI:MGI.
DR GO; GO:0043408; P:regulation of MAPK cascade; IGI:MGI.
DR GO; GO:0045664; P:regulation of neuron differentiation; ISO:MGI.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.
DR GO; GO:0001666; P:response to hypoxia; IMP:MGI.
DR GO; GO:0014044; P:Schwann cell development; IMP:MGI.
DR GO; GO:0036135; P:Schwann cell migration; IMP:MGI.
DR GO; GO:0014010; P:Schwann cell proliferation; IMP:MGI.
DR GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
DR GO; GO:0048745; P:smooth muscle tissue development; IMP:MGI.
DR GO; GO:0021510; P:spinal cord development; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IGI:MGI.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI.
DR GO; GO:1904738; P:vascular associated smooth muscle cell migration; IGI:MGI.
DR GO; GO:1990874; P:vascular associated smooth muscle cell proliferation; IGI:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR GO; GO:0042060; P:wound healing; IMP:MGI.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.10.506.10; -; 5.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; PTHR10194; 2.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW GTPase activation; Lipid-binding; Nucleus; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P97526"
FT CHAIN 2..2841
FT /note="Neurofibromin"
FT /id="PRO_0000056666"
FT DOMAIN 1237..1453
FT /note="Ras-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00167"
FT DOMAIN 1582..1740
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1582..1839
FT /note="Lipid binding"
FT /evidence="ECO:0000250"
FT REGION 2786..2841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 2557..2573
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 2805..2833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P97526"
FT MOD_RES 866
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 878
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2190
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT MOD_RES 2469
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2516
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2517
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT MOD_RES 2525
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2545
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT MOD_RES 2567
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT MOD_RES 2599
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2804
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT MOD_RES 2819
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21359"
FT VAR_SEQ 1373..1393
FT /note="Missing (in isoform I and isoform IV)"
FT /evidence="ECO:0000305"
FT /id="VSP_001633"
FT VAR_SEQ 1394..1406
FT /note="VVSQRFPQNSIGA -> VPKSSCFSCLNNRWLASASLRTASVP (in
FT isoform III and isoform IV)"
FT /evidence="ECO:0000305"
FT /id="VSP_001634"
FT VAR_SEQ 1407..2841
FT /note="Missing (in isoform III and isoform IV)"
FT /evidence="ECO:0000305"
FT /id="VSP_001635"
SQ SEQUENCE 2841 AA; 319596 MW; 06650BDCDC531002 CRC64;
MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTT
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
LHTCREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NVDVHDIELL
QYINVDCAKL KRLLKETAFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT
DMAECAEKLF DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ESNINKKLFL
DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP
SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN
SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK
PTDLETRSYK CLLLSMVKLI HADPKLLLCN PRKQGPETQS STAELITGLV QLVPQSHMPE
VAQEAMEALL VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL
REILICRNKF LLKNKQADRS SCHSLYLYGV GCEMSATGNT TQMSVDHDEF LRACTPGASL
RKGRGNSSMD STAGCSGTPP ICRQAQTKLE VALYMFLWNP DTEAVLVAMS CFRHLCEEAD
IRCGVDEVSV HNFLPNYNTF MEFASVSNMM STGRAALQKR VMALLRRIEH PTAGNIEAWE
DTHAKWEQAT KLILNYPKAK MEDGQAAESL HKTIVKRRMS HVSGGGSIDL SDTDSLQEWI
NMTGFLCALG GVCLQQRSSS GLATYSPPMG AVSERKGSMI SVMSSEGNID SPVSRFMDRL
LSLMVCNHEK VGLQIRTNVK DLVGLELSPA LYPMLFNKLK NTISKFFDSQ GQVLLSDSNT
QFVEQTIAIM KNLLDNHTEG SSEHLGQASI ETMMLNLVRY VRVLGNMVHA IQIKTKLCQL
VEVMMARRDD LSFCQEMKFR NKMVEYLTDW VMGTSNQAAD DDIKCLTRDL DQASMEAVVS
LLAGLPLQPE EGDGVELMEA KSQLFLKYFT LFMNLLNDCS EVEDENAQTG GRKRGMSRRL
ASLRHCTVLA MSNLLNANVD SGLMHSIGLG YHKDLQTRAT FMEVLTKILQ QGTEFDTLAE
TVLADRFERL VELVTMMGDQ GELPIAMALA NVVPCSQWDE LARVLVTLFD SRHLLYQLLW
NMFSKEVELA DSMQTLFRGN SLASKIMTFC FKVYGATYLQ KLLDPLLRVI ITSSDWQHVS
FEVDPTRLEP SESLEENQRN LLQMTEKFFH AIISSSSEFP SQLRSVCHCL YQATCHSLLN
KATVKERKEN KKSVVSQRFP QNSIGAVGSA MFLRFINPAI VSPYEAGILD KKPPPRIERG
LKLMSKVLQS IANHVLFTKE EHMRPFNDFV KSNFDLARRF FLDIASDCPT SDAVNHSLSF
ISDGNVLALH RLLWNNQEKI GQYLSSNRDH KAVGRRPFDK MATLLAYLGP PEHKPVADTH
WSSLNLTSSK FEEFMTRHQV HEKEEFKALK TLSIFYQAGT SKAGNPIFYY VARRFKTGQI
NGDLLIYHVL LTLKPYYAKP YEIVVDLTHT GPSNRFKTDF LSKWFVVFPG FAYDNVSAVY
IYNCNSWVRE YTKYHERLLT GLKGSKRLIF IDCPGKLAEH IEHEQQKLPA ATLALEEDLK
VFHNALKLAH KDTKVSIKVG STAVQVTSAE RTKVLGQSVF LNDIYYASEI EEICLVDENQ
FTLTIANQGT PLTFMHQECE AIVQSIIHIR TRWELSQPDS IPQHTKIRPK DVPGTLLNIA
LLNLGSSDPS LRSAAYNLLC ALTCTFNLKI EGQLLETSGL CIPANNTLFI VSISKTLAAN
EPHLTLEFLE ECISGFSKSS IELKHLCLEY MTPWLSNLVR FCKHNDDAKR QRVTAILDKL
ITMTINEKQM YPSIQAKIWG SLGQITDLLD VVLDSFIKTS ATGGLGSIKA EVMADTAVAL
ASGNVKLVSS KVIGRMCKII DKTCLSPTPT LEQHLMWDDI AILARYMLML SFNNSLDVAA
HLPYLFHVVT FLVATGPLSL RASTHGLLIN IIHSLCTCSQ LHFSEETKQV LRLSLTEFSL
PKFYLLFGIS KVKSAAVIAF RSSYRDRSFS PGSYERETFA LTSLETVTEA LLEIMEACMR
DIPTCKWLDQ WTELAQRFAF QYNPSLQPRA LVVFGCISKR VSHGQIKQII RILSKALESC
LKGPDTYNSQ VLIESTVIAL TKLQPLLNKD SPLHKALFWV AVAVLQLDEV NLYSAGTALL
EQNLHTLDSL RIFNDKSPEE VFMAIRNPLE WHCKQMDHFV GLNFNSNFNF ALVGHLLKGY
RHPSPAIVAR TVRILHTLLT LVNKHRNCDK FEVNTQSVAY LAALLTVSEE VRSRCSLKHR
KSLLLTDISM ENVPMDTYPI HHGDPSYRTL KETQPWSSPK GSEGYLAATY PAVGQTSPRA
RKSMSLDMGQ PSQANTKKLL GTRKSFDHLI SDTKAPKRQE MESGITTPPK MRRVAETDYE
METQRIPSSQ QHPHLRKVSV SESNVLLDEE VLTDPKIQAL LLTVLATLVK YTTDEFDQRI
LYEYLAEASV VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPIHGIVQSV VYHEESPPQY
QTSYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE ETSEESLLTP
TSPYPPALQS QLSITANLNL SNSMTSLATS QHSPGLDKEN VELSPTAGHC NSGRTRHGSA
SQVQKQRSAG SFKRNSIKKI V
