ID   NF2IP_XENTR             Reviewed;         434 AA.
AC   Q0P4K8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=NFATC2-interacting protein;
DE   AltName: Full=Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein;
GN   Name=nfatc2ip;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the magnitude of NFAT-driven transcription of a
CC       specific subset of cytokine genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC122026; AAI22027.1; -; mRNA.
DR   RefSeq; NP_001072535.1; NM_001079067.1.
DR   AlphaFoldDB; Q0P4K8; -.
DR   SMR; Q0P4K8; -.
DR   DNASU; 779990; -.
DR   GeneID; 779990; -.
DR   KEGG; xtr:779990; -.
DR   CTD; 84901; -.
DR   Xenbase; XB-GENE-6457267; nfatc2ip.
DR   InParanoid; Q0P4K8; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR022617; Rad60/SUMO-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF11976; Rad60-SLD; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..434
FT                   /note="NFATC2-interacting protein"
FT                   /id="PRO_0000281012"
FT   DOMAIN          275..351
FT                   /note="Ubiquitin-like"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  47332 MW;  212B6EE22F8564BC CRC64;
     MGSPTWLQGE KSSPNARGQH SPGFCPSGPQ PCPKPRGPQP CPKPRGPQPC PKPRGPQPCT
     PALLWAPHRL EGLSQSQDGL LPTSPCFVSG TEAPTACGPC IDIESGSPHR YEASEESSDS
     DVELVRPRQV KRRRLLPGTV PASVSVYSNK VNSSLKLPPD NSKALLQMSE LHSIRGSEDV
     ESEIVPPVTQ QKPPTKELTD SETDETEPPN TERLRTGSPS PPPTPKTPVR RKGRAYNKIR
     EMDARLRDLG TVLSPGQKVT TEENDVIVVG SSPAPELTVK VRRGGKLFRI NLAMWDPLEK
     LAQSMASQLN VEPSRILLLL GDEELNKSQT PKSMNLTVAD IIDCVVLSPP DGQEDSDPNE
     KICIKVQGKE KQSHLSVMVG KVEPLQSLMD QYQAAMGLTK KHKVSFFFEG QKLKGKNTAE
     ELGLESDDII EVWA