NF2L3_MOUSE
ID NF2L3_MOUSE Reviewed; 660 AA.
AC Q9WTM4;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Nuclear factor erythroid 2-related factor 3;
DE Short=NF-E2-related factor 3;
DE Short=NFE2-related factor 3;
DE AltName: Full=Nuclear factor, erythroid derived 2, like 3;
GN Name=Nfe2l3; Synonyms=Nrf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC STRAIN=ICR; TISSUE=Brain;
RX PubMed=10037736; DOI=10.1074/jbc.274.10.6443;
RA Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K.,
RA Hayashi N., Yamamoto M.;
RT "Molecular cloning and functional characterization of a new Cap'n' collar
RT family transcription factor Nrf3.";
RL J. Biol. Chem. 274:6443-6452(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15060151; DOI=10.1128/mcb.24.8.3286-3294.2004;
RA Derjuga A., Gourley T.S., Holm T.M., Heng H.H.Q., Shivdasani R.A.,
RA Ahmed R., Andrews N.C., Blank V.;
RT "Complexity of CNC transcription factors as revealed by gene targeting of
RT the Nrf3 locus.";
RL Mol. Cell. Biol. 24:3286-3294(2004).
CC -!- FUNCTION: Activates erythroid-specific, globin gene expression.
CC -!- SUBUNIT: Heterodimer with MAFG, MAFK and other small MAF proteins that
CC binds to the MAF recognition elements (MARE). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- TISSUE SPECIFICITY: High level expression in brain, thymus, testis and
CC placenta. Medium level expression in uterus, stomach and lung. Low
CC level expression in kidney. No expression in heart, liver, spleen and
CC ovary. {ECO:0000269|PubMed:15060151}.
CC -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily. {ECO:0000305}.
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DR EMBL; AB013852; BAA76289.1; -; mRNA.
DR EMBL; BC005416; AAH05416.1; -; mRNA.
DR CCDS; CCDS20134.1; -.
DR RefSeq; NP_035033.1; NM_010903.1.
DR AlphaFoldDB; Q9WTM4; -.
DR SMR; Q9WTM4; -.
DR STRING; 10090.ENSMUSP00000005103; -.
DR PaxDb; Q9WTM4; -.
DR PRIDE; Q9WTM4; -.
DR Antibodypedia; 12307; 184 antibodies from 27 providers.
DR DNASU; 18025; -.
DR Ensembl; ENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
DR GeneID; 18025; -.
DR KEGG; mmu:18025; -.
DR UCSC; uc009bxl.1; mouse.
DR CTD; 9603; -.
DR MGI; MGI:1339958; Nfe2l3.
DR VEuPathDB; HostDB:ENSMUSG00000029832; -.
DR eggNOG; KOG3863; Eukaryota.
DR GeneTree; ENSGT00950000182892; -.
DR HOGENOM; CLU_024173_1_0_1; -.
DR InParanoid; Q9WTM4; -.
DR OMA; LKRWWSA; -.
DR OrthoDB; 1095280at2759; -.
DR PhylomeDB; Q9WTM4; -.
DR TreeFam; TF337360; -.
DR BioGRID-ORCS; 18025; 5 hits in 76 CRISPR screens.
DR ChiTaRS; Nfe2l3; mouse.
DR PRO; PR:Q9WTM4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9WTM4; protein.
DR Bgee; ENSMUSG00000029832; Expressed in urinary bladder urothelium and 152 other tissues.
DR ExpressionAtlas; Q9WTM4; baseline and differential.
DR Genevisible; Q9WTM4; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR029854; NF2L3.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR24411:SF8; PTHR24411:SF8; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..660
FT /note="Nuclear factor erythroid 2-related factor 3"
FT /id="PRO_0000076453"
FT DOMAIN 541..604
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 120..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..562
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 566..573
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 142..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 72707 MW; F5CBEEA77E6F4438 CRC64;
MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT RPASASNPFS
ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH SVATGNADGA HGLLGTAASS
AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE EKAAEPTAQV PDAGGCGSQE NGMLREKSEA
VDHSSQQEEN EEGVSAQAKS RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL
EDLFQLLSSQ PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS QDLLYDLDSN
IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS LTNSYRIYDG TVGYNSDLQS
LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH VSLECQQVFH DHTYHLQSGA SEPTSESFAW
SEKSQKTSGC LDNPDRNLSR DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS
LIRDIRRRGK NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE APKGKRERRN
