NF2_CONMR
ID NF2_CONMR Reviewed; 92 AA.
AC P0DM19;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 1.
DT 25-MAY-2022, entry version 12.
DE RecName: Full=Conotoxin Mr15.2 {ECO:0000305};
DE AltName: Full=Mr094 {ECO:0000303|PubMed:23152539};
DE Flags: Precursor;
OS Conus marmoreus (Marble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX NCBI_TaxID=42752;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=23152539; DOI=10.1074/mcp.m112.021469;
RA Dutertre S., Jin A.H., Kaas Q., Jones A., Alewood P.F., Lewis R.J.;
RT "Deep venomics reveals the mechanism for expanded peptide diversity in cone
RT snail venom.";
RL Mol. Cell. Proteomics 12:312-329(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23152539}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:23152539}.
CC -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C). {ECO:0000305}.
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin N superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0DM19; -.
DR TCDB; 8.B.16.3.3; the maurocalcine (maca) family.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..53
FT /evidence="ECO:0000305|PubMed:23152539"
FT /id="PRO_0000444685"
FT CHAIN 54..92
FT /note="Conotoxin Mr15.2"
FT /evidence="ECO:0000269|PubMed:23152539"
FT /id="PRO_0000444686"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 92 AA; 10081 MW; 3AF9373122343B3B CRC64;
MSTLKMMLLI LLLLLPMATF DSDGQAIPGG GIPSAVNSRV GGDEKSGRSL EKRCRSGKTC
PRVGPDVCCE RSDCFCKLVP ARPFWRYRCI CL