NF60_DORPE
ID NF60_DORPE Reviewed; 511 AA.
AC Q01240;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=60 kDa neurofilament protein;
DE Short=NF60;
OS Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Doryteuthis.
OX NCBI_TaxID=1051067;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=1869540; DOI=10.1016/s0021-9258(18)98582-0;
RA Szaro B.G., Pant H.C., Way J., Battey J.;
RT "Squid low molecular weight neurofilament proteins are a novel class of
RT neurofilament protein. A nuclear lamin-like core and multiple distinct
RT proteins formed by alternative RNA processing.";
RL J. Biol. Chem. 266:15035-15041(1991).
CC -!- FUNCTION: Major squid neurofilament protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=NF60;
CC IsoId=Q01240-1; Sequence=Displayed;
CC Name=NF70;
CC IsoId=Q01241-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; M64717; AAA29992.1; -; mRNA.
DR PIR; A39340; A39340.
DR AlphaFoldDB; Q01240; -.
DR SMR; Q01240; -.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR Pfam; PF00038; Filament; 1.
DR PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Intermediate filament.
FT CHAIN 1..511
FT /note="60 kDa neurofilament protein"
FT /id="PRO_0000063855"
FT DOMAIN 96..449
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..99
FT /note="Head"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..135
FT /note="Coil 1A"
FT REGION 136..145
FT /note="Linker 1"
FT REGION 146..284
FT /note="Coil 1B"
FT REGION 285..303
FT /note="Linker 12"
FT REGION 304..449
FT /note="Coil 2"
FT REGION 450..511
FT /note="Tail"
FT REGION 479..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 59161 MW; 58569544520DCF24 CRC64;
MSVTQKKTEI STTTTYEGES RPSSGMSGFS YSAKIHPRTS GYINRSSQSP FRSSMGSNAA
YTRSYDFSYG ATAMPGRYAN ISSTGVNHVK ANREREKQDM RDLNERFANY IEKVRFLEAQ
NKKLAGELEE LKSKWGKETS AIKEMYETEL EEARKLIDAT NKEKITLDVR VTELIDQLER
QQKDLEESRT YHQIDQEQIA RQNQQLADLE GEISMLRRSI ESLEKEKMRQ SNILAKMNDE
MEKMRMDLNN ETINHLDAEN RRQTLEEELE FQKDVHAQEL KELAALAYRD TTAENREFWR
NELAQAIRDI QQEYDAKCDQ MRGDIEAYYN LKVQEFRTGA TKQNMEVTRN KEENTKLKSN
MTEIRNRLAD LEARNAQLER TNQDLLRDLE EKDRQNELES CQYKEEITKL RGEMESILKE
LQDLMDIKLS LELEIAAYRK LLEGEESRVG MKQIVEQVVG ARPNEAEVLS TILTRSEGGY
EATGGITTTT TTSSQERRSM SEEKKSMGSS D