ID   NF70_DORPE              Reviewed;         615 AA.
AC   Q01241;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=70 kDa neurofilament protein;
DE            Short=NF70;
OS   Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Doryteuthis.
OX   NCBI_TaxID=1051067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=1869540; DOI=10.1016/s0021-9258(18)98582-0;
RA   Szaro B.G., Pant H.C., Way J., Battey J.;
RT   "Squid low molecular weight neurofilament proteins are a novel class of
RT   neurofilament protein. A nuclear lamin-like core and multiple distinct
RT   proteins formed by alternative RNA processing.";
RL   J. Biol. Chem. 266:15035-15041(1991).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=NF70;
CC         IsoId=Q01241-1; Sequence=Displayed;
CC       Name=NF60;
CC         IsoId=Q01240-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; M64718; AAA29993.1; -; mRNA.
DR   PIR; B39340; B39340.
DR   AlphaFoldDB; Q01241; -.
DR   SMR; Q01241; -.
DR   PRIDE; Q01241; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1260; -; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   Pfam; PF00038; Filament; 1.
DR   PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF74853; SSF74853; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Intermediate filament.
FT   CHAIN           1..615
FT                   /note="70 kDa neurofilament protein"
FT                   /id="PRO_0000063856"
FT   DOMAIN          96..449
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   DOMAIN          499..612
FT                   /note="LTD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT   REGION          1..99
FT                   /note="Head"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..135
FT                   /note="Coil 1A"
FT   REGION          136..145
FT                   /note="Linker 1"
FT   REGION          146..284
FT                   /note="Coil 1B"
FT   REGION          285..303
FT                   /note="Linker 12"
FT   REGION          304..449
FT                   /note="Coil 2"
FT   REGION          450..615
FT                   /note="Tail"
SQ   SEQUENCE   615 AA;  71002 MW;  7AE7838A63484F11 CRC64;
     MSVTQKKTEI STTTTYEGES RPSSGMSGFS YSAKIHPRTS GYINRSSQSP FRSSMGSNAA
     YTRSYDFSYG ATAMPGRYAN ISSTGVNHVK ANREREKQDM RDLNERFANY IEKVRFLEAQ
     NKKLAGELEE LKSKWGKETS AIKEMYETEL EEARKLIDAT NKEKITLDVR VTELIDQLER
     QQKDLEESRT YHQIDQEQIA RQNQQLADLE GEISMLRRSI ESLEKEKMRQ SNILAKMNDE
     MEKMRMDLNN ETINHLDAEN RRQTLEEELE FQKDVHAQEL KELAALAYRD TTAENREFWR
     NELAQAIRDI QQEYDAKCDQ MRGDIEAYYN LKVQEFRTGA TKQNMEVTRN KEENTKLKSN
     MTEIRNRLAD LEARNAQLER TNQDLLRDLE EKDRQNELES CQYKEEITKL RGEMESILKE
     LQDLMDIKLS LELEIAAYRK LLEGEESRVG MKQIVEQVVG ARPNEAEVLS TILTRSEGGY
     EATGDSQISM KMMRGELAAK TTYQRTSKGS VSIKEADSQG CFIALETKKE ENLTGWKIVR
     KVDDNKVYTY EIPNLVLKTG TVVKIWSKNH QAQARGDDLV SRENDTWGTG SNVVTILQNE
     KGEDKANYTQ NTVYQ