NF7O_XENLA
ID NF7O_XENLA Reviewed; 610 AA.
AC Q91431; Q801R9;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Nuclear factor 7, ovary;
DE Short=xNF7-O;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB35876.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Ovary {ECO:0000269|PubMed:8541218};
RX PubMed=8541218; DOI=10.1016/0925-4773(95)00410-3;
RA Gong S.-G., Reddy B.A., Etkin L.D.;
RT "Two forms of Xenopus nuclear factor 7 have overlapping spatial but
RT different temporal patterns of expression during development.";
RL Mech. Dev. 52:305-318(1995).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH47956.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH47956.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that determines dorsal-ventral body
CC axis. {ECO:0000269|PubMed:8541218}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q92021}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:8541218};
CC IsoId=Q91431-1; Sequence=Displayed;
CC Name=2 {ECO:0000305};
CC IsoId=Q91431-2; Sequence=VSP_051606;
CC -!- TISSUE SPECIFICITY: Abundant in oocytes. At the neurula stage, low
CC expression in dorsal embryo region including neural folds and somites.
CC {ECO:0000269|PubMed:8541218}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:8541218}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47956.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; S80988; AAB35876.1; -; mRNA.
DR EMBL; BC047956; AAH47956.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001079694.2; NM_001086225.2. [Q91431-1]
DR AlphaFoldDB; Q91431; -.
DR SMR; Q91431; -.
DR IntAct; Q91431; 2.
DR DNASU; 379381; -.
DR GeneID; 379381; -.
DR KEGG; xla:379381; -.
DR CTD; 379381; -.
DR Xenbase; XB-GENE-6256071; xnf7.S.
DR OrthoDB; 423686at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 379381; Expressed in neurula embryo and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Developmental protein; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..610
FT /note="Nuclear factor 7, ovary"
FT /id="PRO_0000055978"
FT DOMAIN 21..75
FT /note="Tudor-knot"
FT /evidence="ECO:0000255"
FT DOMAIN 415..610
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 146..186
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 220..261
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 79..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..374
FT /evidence="ECO:0000255"
FT COMPBIAS 96..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 225
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 228
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 247
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 253
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT MOD_RES 104
FT /note="Phosphothreonine; by CDK1"
FT /evidence="ECO:0000250"
FT VAR_SEQ 62..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_051606"
FT CONFLICT 265
FT /note="I -> V (in Ref. 2; AAH47956)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="R -> A (in Ref. 2; AAH47956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 69115 MW; D828F60060572EC1 CRC64;
MEEDEGADDG EQEEEEVLLV NVGSTYPCKR SDGSQHDADI VKTRYNKQAG REEYYVHYVG
LNRRQNEWVD KSRLVLTKPP KEVETNGTDQ EEMTEPTEQP DSKTPQKRKL EEPEPEPKKA
KVEDKDASKT AASLGAAGDF AEELTCPLCV ELFKDPVMVA CGHNFCRSCI DKVWEGQSSF
ACPECKESIT DRKYTINRVL ANLAKKAACT PVTPVEKKTR PLEKCSEHDE RLKLYCKDDG
TLGCVICRDS LKHASHNFLP ILDAIGVYRE ELSAIVAPLE ASLKVTEQLS GEQSDKIEQH
NKNVSQYKEH VTSEFEKLHK FLKEREEKLL EQLKEQGDNL LTEMENNLVK MQENQDAIKK
TISLAKERME ETDSISFLTD IKTFIDKCQE QQRAVISTGN TLLSKELCQG TFKGPIQYIM
WKELKSVITP SLTPMLLDPN SAHPNLHLSD GLTSVRYGEN KLSLPDNPKR FSQCILVLGS
QGFDSGRHYW EVEVGDKTAW DVGMASESSN RKGKIKLNPK NGYWAIWLRN GNRYKALESP
SKALSLTSHP RKIGVYVDYE GGQISFYNAD NMTIIYTFSA TFTEKLYPYL SPFLHDSGKN
VDALRFVHNQ
